Asymmetric synthesis of various chiral 5-pyrimidyl-alkanols by the enantios elective alkylation of pyrimidine-5-carbaldehydes with dialkylzincs in the presence of chiral amino alcohols

Takanori Shibata, Tadakatsu Hayase, Yasuyuki Aiba, Hayami Tabira, Kenso Soai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

(1S,2R)-N,N-Dibutylnorephedrine catalyzes the enantioselective addition of dialkylzincs to various pyrimidine-5-carbaldehydes. Ethylation and butylation proceed with high enantioselectivities (up to 94% e.e.) to give optically active secondary 5-pyrimidyl alkanols.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalHeterocycles
Volume46
Issue number1
DOIs
Publication statusPublished - 1997 Jan 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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