Asymmetric total synthesis of (+)-carneic acid A and structure revision of its natural form

Shuhei Yamakoshi, Nobuyuki Hayashi, Takahiro Suzuki, Masahisa Nakada

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

This Letter describes the asymmetric total synthesis of (+)-carneic acid A via the stereoselective IMDA reaction of (E,E,E)-triene, which was prepared from the commercially available methyl (S)-3-hydroxy-2-methylpropionate. By this asymmetric total synthesis, we verified that the reported absolute structure of naturally occurring carneic acid A must be revised.

Original languageEnglish
Pages (from-to)5372-5375
Number of pages4
JournalTetrahedron Letters
Volume50
Issue number38
DOIs
Publication statusPublished - 2009 Sep 23

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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