A new asymmetric total synthesis of enantiopure (-)-methyl jasmonate is described. This synthesis was accomplished starting from the new enantiopure building block prepared via the catalytic asymmetric intramolecular cyclopropanation (IMCP) of the α-diazo-β-keto 1-naphthyl sulfone, which was devised to give good selectivity both in the IMCP reaction and in the C-alkynylation of the intermediate required for the total synthesis of enantiopure (-)-methyl jasmonate.
- Catalytic asymmetric synthesis
- Chiral building blocks
- Intramolecular cyclopropanation
- Total synthesis
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry