Asymmetric vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals in total syntheses of natural products

Seijiro Hosokawa, Kuniaki Tatsuta

    Research output: Contribution to journalArticle

    52 Citations (Scopus)

    Abstract

    Asymmetric vinylogous aldol reaction is a powerful methodology to introduce a multi functional group in the stereoselective manner. Recently, we have developed highly stereoselective vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals possessing the chiral oxazolidone. Our methodology has been applied to the asymmetric syntheses of natural products to establish the short and efficient routes. This review focuses on the asymmetric vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals in total syntheses of natural products.

    Original languageEnglish
    Pages (from-to)1-18
    Number of pages18
    JournalMini-Reviews in Organic Chemistry
    Volume5
    Issue number1
    DOIs
    Publication statusPublished - 2008 Feb

    Fingerprint

    Acetals
    Biological Products
    Functional groups
    3-hydroxybutanal

    Keywords

    • Natural product
    • Polyketide
    • Remote stereoinduction
    • Total synthesis
    • Vinylketene N,O-acetal
    • Vinylogous Mukaiyama aldol reaction

    ASJC Scopus subject areas

    • Organic Chemistry

    Cite this

    Asymmetric vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals in total syntheses of natural products. / Hosokawa, Seijiro; Tatsuta, Kuniaki.

    In: Mini-Reviews in Organic Chemistry, Vol. 5, No. 1, 02.2008, p. 1-18.

    Research output: Contribution to journalArticle

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