Asymmetric vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals in total syntheses of natural products

Seijiro Hosokawa, Kuniaki Tatsuta

Research output: Contribution to journalReview article

53 Citations (Scopus)

Abstract

Asymmetric vinylogous aldol reaction is a powerful methodology to introduce a multi functional group in the stereoselective manner. Recently, we have developed highly stereoselective vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals possessing the chiral oxazolidone. Our methodology has been applied to the asymmetric syntheses of natural products to establish the short and efficient routes. This review focuses on the asymmetric vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals in total syntheses of natural products.

Original languageEnglish
Pages (from-to)1-18
Number of pages18
JournalMini-Reviews in Organic Chemistry
Volume5
Issue number1
DOIs
Publication statusPublished - 2008 Feb 1

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Keywords

  • Natural product
  • Polyketide
  • Remote stereoinduction
  • Total synthesis
  • Vinylketene N,O-acetal
  • Vinylogous Mukaiyama aldol reaction

ASJC Scopus subject areas

  • Organic Chemistry

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