Athlome project consortium: A concerted effort to discover genomic and other "omic" markers of athletic performance

Athlome Project Consortium

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Despite numerous attempts to discover genetic variants associated with elite athletic performance, injury predisposition, and elite/world-class athletic status, there has been limited progress to date. Past reliance on candidate gene studies predominantly focusing on genotyping a limited number of single nucleotide polymorphisms or the insertion/deletion variants in small, often heterogeneous cohorts (i.e., made up of athletes of quite different sport specialties) have not generated the kind of results that could offer solid opportunities to bridge the gap between basic research in exercise sciences and deliverables in biomedicine. A retrospective view of genetic association studies with complex disease traits indicates that transition to hypothesis-free genome-wide approaches will be more fruitful. In studies of complex disease, it is well recognized that the magnitude of genetic association is often smaller than initially anticipated, and, as such, large sample sizes are required to identify the gene effects robustly. A symposium was held in Athens and on the Greek island of Santorini from 14 -17 May 2015 to review the main findings in exercise genetics and genomics and to explore promising trends and possibilities. The symposium also offered a forum for the development of a position stand (the Santorini Declaration). Among the participants, many were involved in ongoing collaborative studies (e.g., ELITE, GAMES, Gene SMART, GENESIS, and POWERGENE). A consensus emerged among participants that it would be advantageous to bring together all current studies and those recently launched into one new large collaborative initiative, which was subsequently named the Athlome Project Consortium.

Original languageEnglish
Pages (from-to)183-190
Number of pages8
JournalPhysiological Genomics
Volume48
Issue number3
DOIs
Publication statusPublished - 2016 Mar 1

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Athletic Performance
Sports
Exercise
Genes
Athletic Injuries
Genetic Association Studies
Genomics
Islands
Athletes
Sample Size
Single Nucleotide Polymorphism
Genome
Research

Keywords

  • Genetics
  • Performance
  • Sports genomics

ASJC Scopus subject areas

  • Physiology
  • Genetics

Cite this

Athlome project consortium : A concerted effort to discover genomic and other "omic" markers of athletic performance. / Athlome Project Consortium.

In: Physiological Genomics, Vol. 48, No. 3, 01.03.2016, p. 183-190.

Research output: Contribution to journalReview article

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