Autologous formalin-fixed tumor vaccine for initially-diagnosed glioblastoma

Takashi Maruyama, Yoshihiro Muragaki, Eiichi Ishikawa, Koji Tsuboi, Hiroshi Iseki, Tadao Ohno, Akira Matsumura, Yoshikazu Okada

    Research output: Contribution to journalArticle

    Abstract

    There has been little improvement in the prognosis of glioblastoma multiforme (GBM) despite a number of therapeutic modalities that have been developed. Immunotherapy presents a therapeutic challenge with a different strategy from radiation therapy and chemotherapy. Based on the tumor-specific immune reactions, Ohno's group developed the use of formalin-fixed sections instead of live target tumor cells and formulated an autologous formalin-fixed tumor vaccine (AFTV). This paper reports the results of preliminary clinical trials and prospective clinical trial directed to the evaluation of the therapeutic efficacy of the AFTV concomitant with fractionated radiotherapy (FRT) in cases of initially-diagnosed glioblastoma multiforme (GBM).

    Original languageEnglish
    Pages (from-to)448-455
    Number of pages8
    JournalBiotherapy
    Volume24
    Issue number6
    Publication statusPublished - 2010 Nov 1

    Keywords

    • Autologous formalin-fixed tumor vaccine
    • Clinical trial
    • Glioblastoma

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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  • Cite this

    Maruyama, T., Muragaki, Y., Ishikawa, E., Tsuboi, K., Iseki, H., Ohno, T., Matsumura, A., & Okada, Y. (2010). Autologous formalin-fixed tumor vaccine for initially-diagnosed glioblastoma. Biotherapy, 24(6), 448-455.