Autophagy-deficient mice develop multiple liver tumors

Akito Takamura, Masaaki Komatsu, Taichi Hara, Ayako Sakamoto, Chieko Kishi, Satoshi Waguri, Yoshinobu Eishi, Okio Hino, Keiji Tanaka, Noboru Mizushima

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Abstract

Autophagy is a major pathway for degradation of cytoplasmic proteins and organelles, and has been implicated in tumor suppression. Here, we report that mice with systemic mosaic deletion of Atg5 and liver-specific Atg7-/- mice develop benign liver adenomas. These tumor cells originate autophagy-deficient hepatocytes and show mitochondrial swelling, p62 accumulation, and oxidative stress and genomic damage responses. The size of the Atg7-/- liver tumors is reduced by simultaneous deletion of p62. These results suggest that autophagy is important for the suppression of spontaneous tumorigenesis through a cellintrinsic mechanism, particularly in the liver, and that p62 accumulation contributes to tumor progression.

Original languageEnglish
Pages (from-to)795-800
Number of pages6
JournalGenes and Development
Volume25
Issue number8
DOIs
Publication statusPublished - 2011 Apr 15

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Keywords

  • Autophagy
  • Model mouse
  • Oxidative stress
  • Tumorigenesis

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino, O., Tanaka, K., & Mizushima, N. (2011). Autophagy-deficient mice develop multiple liver tumors. Genes and Development, 25(8), 795-800. https://doi.org/10.1101/gad.2016211