Axinelloside A, an unprecedented highly sulfated lipopolysaccharide inhibiting telomerase, from the marine sponge, Axinella infundibula

Kaoru Warabi, Toshiyuki Hamada, Youichi Nakao, Shigeki Matsunaga, Hiroshi Hirota, Rob W M Van Soest, Nobuhiro Fusetani

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Axinelloside A was isolated from the lipophilic extract of the Japanease marine sponge Axinella infundibula as a strong human telomerase inhibitor (IC50 2.0 μg/mL). It has the molecular weight of 4780.4 as the monoisotopic mass of the 19 sodium salt. The chemical structure was elucidated mainly by spectroscopic methods (2D NMR and MS). Axinelloside A consists of twelve sugars, e.g., a scyllo-inositol, a D-arabinose, 5 D-galactoses, and 5 L-fucoses, together with an (R)-3-hydroxy-octadecanoic acid, 3 (E)-2-hexadecenoic acids, and 19 sulfates.

Original languageEnglish
Pages (from-to)13262-13270
Number of pages9
JournalJournal of the American Chemical Society
Volume127
Issue number38
DOIs
Publication statusPublished - 2005 Sep 28
Externally publishedYes

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Axinella
Telomerase
Porifera
Pituitary Gland
Lipopolysaccharides
Arabinose
Fucose
Acids
Galactose
Sugars
Inhibitory Concentration 50
Sulfates
Salts
Molecular Weight
Sodium
Molecular weight
Nuclear magnetic resonance
axinelloside A

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Axinelloside A, an unprecedented highly sulfated lipopolysaccharide inhibiting telomerase, from the marine sponge, Axinella infundibula. / Warabi, Kaoru; Hamada, Toshiyuki; Nakao, Youichi; Matsunaga, Shigeki; Hirota, Hiroshi; Van Soest, Rob W M; Fusetani, Nobuhiro.

In: Journal of the American Chemical Society, Vol. 127, No. 38, 28.09.2005, p. 13262-13270.

Research output: Contribution to journalArticle

Warabi, Kaoru ; Hamada, Toshiyuki ; Nakao, Youichi ; Matsunaga, Shigeki ; Hirota, Hiroshi ; Van Soest, Rob W M ; Fusetani, Nobuhiro. / Axinelloside A, an unprecedented highly sulfated lipopolysaccharide inhibiting telomerase, from the marine sponge, Axinella infundibula. In: Journal of the American Chemical Society. 2005 ; Vol. 127, No. 38. pp. 13262-13270.
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AU - Van Soest, Rob W M

AU - Fusetani, Nobuhiro

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