Axinelloside A, an unprecedented highly sulfated lipopolysaccharide inhibiting telomerase, from the marine sponge, Axinella infundibula

Kaoru Warabi, Toshiyuki Hamada, Yoichi Nakao, Shigeki Matsunaga, Hiroshi Hirota, Rob W.M. Van Soest, Nobuhiro Fusetani

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31 Citations (Scopus)

Abstract

Axinelloside A was isolated from the lipophilic extract of the Japanease marine sponge Axinella infundibula as a strong human telomerase inhibitor (IC50 2.0 μg/mL). It has the molecular weight of 4780.4 as the monoisotopic mass of the 19 sodium salt. The chemical structure was elucidated mainly by spectroscopic methods (2D NMR and MS). Axinelloside A consists of twelve sugars, e.g., a scyllo-inositol, a D-arabinose, 5 D-galactoses, and 5 L-fucoses, together with an (R)-3-hydroxy-octadecanoic acid, 3 (E)-2-hexadecenoic acids, and 19 sulfates.

Original languageEnglish
Pages (from-to)13262-13270
Number of pages9
JournalJournal of the American Chemical Society
Volume127
Issue number38
DOIs
Publication statusPublished - 2005 Sep 28

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ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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