Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis

Yoichi Nakao, Satoru Yoshida, Shigeki Matsunaga, Nobuaki Shindoh, Yoh Terada, Koji Nagai, Jun K. Yamashita, A. Ganesan, Rob W.M. Van Soest, Nobuhiro Fusetani

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99 Citations (Scopus)

Abstract

A zoom in on azumamides (1): Azumamides A-E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC50 values of 0.045-1.3 μg mL-1. Their structures were determined on the basis of spectroscopic analysis and chemical degradation. (Chemical Equation Presented)

Original languageEnglish
Pages (from-to)7553-7557
Number of pages5
JournalAngewandte Chemie - International Edition
Volume45
Issue number45
DOIs
Publication statusPublished - 2006 Nov 20
Externally publishedYes

Keywords

  • Angiogenesis
  • Enzymes
  • Inhibitors
  • Natural products
  • Peptides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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    Nakao, Y., Yoshida, S., Matsunaga, S., Shindoh, N., Terada, Y., Nagai, K., Yamashita, J. K., Ganesan, A., Van Soest, R. W. M., & Fusetani, N. (2006). Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis. Angewandte Chemie - International Edition, 45(45), 7553-7557. https://doi.org/10.1002/anie.200602047