Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis

Yoichi Nakao*, Satoru Yoshida, Shigeki Matsunaga, Nobuaki Shindoh, Yoh Terada, Koji Nagai, Jun K. Yamashita, A. Ganesan, Rob W.M. Van Soest, Nobuhiro Fusetani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

106 Citations (Scopus)

Abstract

A zoom in on azumamides (1): Azumamides A-E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC50 values of 0.045-1.3 μg mL-1. Their structures were determined on the basis of spectroscopic analysis and chemical degradation. (Chemical Equation Presented)

Original languageEnglish
Pages (from-to)7553-7557
Number of pages5
JournalAngewandte Chemie - International Edition
Volume45
Issue number45
DOIs
Publication statusPublished - 2006 Nov 20
Externally publishedYes

Keywords

  • Angiogenesis
  • Enzymes
  • Inhibitors
  • Natural products
  • Peptides

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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