Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis

Yoichi Nakao; Satoru Yoshida; Shigeki Matsunaga; Nobuaki Shindoh; Yoh Terada; Koji Nagai; Jun K. Yamashita; A. Ganesan; Rob W.M. Van Soest; Nobuhiro Fusetani

doi:10.1002/anie.200602047

Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis

Yoichi Nakao^*, Satoru Yoshida, Shigeki Matsunaga, Nobuaki Shindoh, Yoh Terada, Koji Nagai, Jun K. Yamashita, A. Ganesan, Rob W.M. Van Soest, Nobuhiro Fusetani

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

108 Citations (Scopus)

Abstract

A zoom in on azumamides (1): Azumamides A-E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC₅₀ values of 0.045-1.3 μg mL^-1. Their structures were determined on the basis of spectroscopic analysis and chemical degradation. (Chemical Equation Presented)

Original language	English
Pages (from-to)	7553-7557
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	45
DOIs	https://doi.org/10.1002/anie.200602047
Publication status	Published - 2006 Nov 20
Externally published	Yes

Keywords

Angiogenesis
Enzymes
Inhibitors
Natural products
Peptides

ASJC Scopus subject areas

Catalysis
Chemistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.200602047

Cite this

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abstract = "A zoom in on azumamides (1): Azumamides A-E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC50 values of 0.045-1.3 μg mL-1. Their structures were determined on the basis of spectroscopic analysis and chemical degradation. (Chemical Equation Presented)",

keywords = "Angiogenesis, Enzymes, Inhibitors, Natural products, Peptides",

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doi = "10.1002/anie.200602047",

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volume = "45",

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T2 - Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis

AU - Nakao, Yoichi

AU - Yoshida, Satoru

AU - Matsunaga, Shigeki

AU - Shindoh, Nobuaki

AU - Terada, Yoh

AU - Nagai, Koji

AU - Yamashita, Jun K.

AU - Ganesan, A.

AU - Van Soest, Rob W.M.

AU - Fusetani, Nobuhiro

PY - 2006/11/20

Y1 - 2006/11/20

N2 - A zoom in on azumamides (1): Azumamides A-E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC50 values of 0.045-1.3 μg mL-1. Their structures were determined on the basis of spectroscopic analysis and chemical degradation. (Chemical Equation Presented)

AB - A zoom in on azumamides (1): Azumamides A-E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC50 values of 0.045-1.3 μg mL-1. Their structures were determined on the basis of spectroscopic analysis and chemical degradation. (Chemical Equation Presented)

KW - Angiogenesis

KW - Enzymes

KW - Inhibitors

KW - Natural products

KW - Peptides

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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