Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis

Youichi Nakao, Satoru Yoshida, Shigeki Matsunaga, Nobuaki Shindoh, Yoh Terada, Koji Nagai, Jun K. Yamashita, A. Ganesan, Rob W M Van Soest, Nobuhiro Fusetani

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

A zoom in on azumamides (1): Azumamides A-E are five new cyclic tetrapeptides isolated from the marine sponge Mycale izuensis. The azumamides display inhibitory activity toward histone deacetylase with IC50 values of 0.045-1.3 μg mL-1. Their structures were determined on the basis of spectroscopic analysis and chemical degradation. (Chemical Equation Presented)

Original languageEnglish
Pages (from-to)7553-7557
Number of pages5
JournalAngewandte Chemie - International Edition
Volume45
Issue number45
DOIs
Publication statusPublished - 2006 Nov 20
Externally publishedYes

Fingerprint

Histone Deacetylases
Spectroscopic analysis
Degradation

Keywords

  • Angiogenesis
  • Enzymes
  • Inhibitors
  • Natural products
  • Peptides

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Azumamides A-E : Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis. / Nakao, Youichi; Yoshida, Satoru; Matsunaga, Shigeki; Shindoh, Nobuaki; Terada, Yoh; Nagai, Koji; Yamashita, Jun K.; Ganesan, A.; Van Soest, Rob W M; Fusetani, Nobuhiro.

In: Angewandte Chemie - International Edition, Vol. 45, No. 45, 20.11.2006, p. 7553-7557.

Research output: Contribution to journalArticle

Nakao, Y, Yoshida, S, Matsunaga, S, Shindoh, N, Terada, Y, Nagai, K, Yamashita, JK, Ganesan, A, Van Soest, RWM & Fusetani, N 2006, 'Azumamides A-E: Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis', Angewandte Chemie - International Edition, vol. 45, no. 45, pp. 7553-7557. https://doi.org/10.1002/anie.200602047
Nakao, Youichi ; Yoshida, Satoru ; Matsunaga, Shigeki ; Shindoh, Nobuaki ; Terada, Yoh ; Nagai, Koji ; Yamashita, Jun K. ; Ganesan, A. ; Van Soest, Rob W M ; Fusetani, Nobuhiro. / Azumamides A-E : Histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis. In: Angewandte Chemie - International Edition. 2006 ; Vol. 45, No. 45. pp. 7553-7557.
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