Bacterial production of short-chain organic acids and trehalose from levulinic acid: A potential cellulose-derived building block as a feedstock for microbial production

Hiroshi Habe, Shun Sato, Tomotake Morita, Tokuma Fukuoka, Kotaro Kirimura, Dai Kitamoto

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    15 Citations (Scopus)


    Levulinic acid (LA) is a platform chemical derived from cellulosic biomass, and the expansion of LA utilization as a feedstock is important for production of a wide variety of chemicals. To investigate the potential of LA as a substrate for microbial conversion to chemicals, we isolated and identified LA-utilizing bacteria. Among the six isolated strains, Pseudomonas sp. LA18T and Rhodococcus hoagie LA6W degraded up to 70. g/L LA in a high-cell-density system. The maximal accumulation of acetic acid by strain LA18T and propionic acid by strain LA6W was 13.6. g/L and 9.1. g/L, respectively, after a 4-day incubation. Another isolate, Burkholderia stabilis LA20W, produced trehalose extracellularly in the presence of 40. g/L LA to approximately 2. g/L. These abilities to produce useful compounds supported the potential of microbial LA conversion for future development and cellulosic biomass utilization.

    Original languageEnglish
    Pages (from-to)381-386
    Number of pages6
    JournalBioresource Technology
    Publication statusPublished - 2015 Feb 1



    • Cellulosic biomass utilization
    • Levulinic acid
    • Microbial production
    • Short-chain organic acid
    • Trehalose

    ASJC Scopus subject areas

    • Bioengineering
    • Environmental Engineering
    • Waste Management and Disposal

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