Abstract
A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.
Original language | English |
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Pages (from-to) | 1911-1914 |
Number of pages | 4 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 73 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2009 |
Externally published | Yes |
Keywords
- Anti-androgen effect
- Banana peel extract
- Inhibitor of 5alpha-reductase
- Mice
- Suppressive effect on benign prostate hyperplasia
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Molecular Biology
- Applied Microbiology and Biotechnology
- Analytical Chemistry
- Organic Chemistry