Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice

Kiichiro Akamine; Tomoyuki Koyama; Kazunaga Yazawa

doi:10.1271/bbb.80770

Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice

Kiichiro Akamine, Tomoyuki Koyama, Kazunaga Yazawa

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

Original language	English
Pages (from-to)	1911-1914
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	73
Issue number	9
DOIs	https://doi.org/10.1271/bbb.80770
Publication status	Published - 2009
Externally published	Yes

Keywords

Anti-androgen effect
Banana peel extract
Inhibitor of 5alpha-reductase
Mice
Suppressive effect on benign prostate hyperplasia

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Biology
Applied Microbiology and Biotechnology
Analytical Chemistry
Organic Chemistry

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abstract = "A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.",

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AU - Koyama, Tomoyuki

AU - Yazawa, Kazunaga

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N2 - A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

AB - A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

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KW - Mice

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