Abstract
A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.
| Original language | English |
|---|---|
| Pages (from-to) | 1911-1914 |
| Number of pages | 4 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 73 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2009 |
| Externally published | Yes |
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Keywords
- Anti-androgen effect
- Banana peel extract
- Inhibitor of 5alpha-reductase
- Mice
- Suppressive effect on benign prostate hyperplasia
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Molecular Biology
- Applied Microbiology and Biotechnology
- Analytical Chemistry
- Organic Chemistry
Cite this
Akamine, K., Koyama, T., & Yazawa, K. (2009). Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice. Bioscience, Biotechnology and Biochemistry, 73(9), 1911-1914. https://doi.org/10.1271/bbb.80770