Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice

Kiichiro Akamine, Tomoyuki Koyama, Kazunaga Yazawa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

Original languageEnglish
Pages (from-to)1911-1914
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number9
DOIs
Publication statusPublished - 2009
Externally publishedYes

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Keywords

  • Anti-androgen effect
  • Banana peel extract
  • Inhibitor of 5alpha-reductase
  • Mice
  • Suppressive effect on benign prostate hyperplasia

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

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