Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice

Kiichiro Akamine, Tomoyuki Koyama, Kazunaga Yazawa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

Original languageEnglish
Pages (from-to)1911-1914
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number9
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Musa
Cell growth
Methanol
Testosterone
Prostate
Seminal Vesicles
Growth
Androgens
Hyperplasia
Prostatic Neoplasms
Oxidoreductases
Cells
Cell Line
boldenone

Keywords

  • Anti-androgen effect
  • Banana peel extract
  • Inhibitor of 5alpha-reductase
  • Mice
  • Suppressive effect on benign prostate hyperplasia

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice. / Akamine, Kiichiro; Koyama, Tomoyuki; Yazawa, Kazunaga.

In: Bioscience, Biotechnology and Biochemistry, Vol. 73, No. 9, 2009, p. 1911-1914.

Research output: Contribution to journalArticle

Akamine, Kiichiro ; Koyama, Tomoyuki ; Yazawa, Kazunaga. / Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice. In: Bioscience, Biotechnology and Biochemistry. 2009 ; Vol. 73, No. 9. pp. 1911-1914.
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