Abstract
A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.
| Original language | English |
|---|---|
| Pages (from-to) | 1911-1914 |
| Number of pages | 4 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 73 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2009 |
| Externally published | Yes |
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Keywords
- Anti-androgen effect
- Banana peel extract
- Inhibitor of 5alpha-reductase
- Mice
- Suppressive effect on benign prostate hyperplasia
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Molecular Biology
- Applied Microbiology and Biotechnology
- Analytical Chemistry
- Organic Chemistry
Cite this
Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice. / Akamine, Kiichiro; Koyama, Tomoyuki; Yazawa, Kazunaga.
In: Bioscience, Biotechnology and Biochemistry, Vol. 73, No. 9, 2009, p. 1911-1914.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice
AU - Akamine, Kiichiro
AU - Koyama, Tomoyuki
AU - Yazawa, Kazunaga
PY - 2009
Y1 - 2009
N2 - A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.
AB - A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.
KW - Anti-androgen effect
KW - Banana peel extract
KW - Inhibitor of 5alpha-reductase
KW - Mice
KW - Suppressive effect on benign prostate hyperplasia
UR - http://www.scopus.com/inward/record.url?scp=70349673580&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349673580&partnerID=8YFLogxK
U2 - 10.1271/bbb.80770
DO - 10.1271/bbb.80770
M3 - Article
C2 - 19734683
AN - SCOPUS:70349673580
VL - 73
SP - 1911
EP - 1914
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 9
ER -