Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice

Kiichiro Akamine; Tomoyuki Koyama; Kazunaga Yazawa

doi:10.1271/bbb.80770

Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice

Kiichiro Akamine, Tomoyuki Koyama^*, Kazunaga Yazawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

Original language	English
Pages (from-to)	1911-1914
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	73
Issue number	9
DOIs	https://doi.org/10.1271/bbb.80770
Publication status	Published - 2009
Externally published	Yes

Keywords

Anti-androgen effect
Banana peel extract
Inhibitor of 5alpha-reductase
Mice
Suppressive effect on benign prostate hyperplasia

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Biology
Applied Microbiology and Biotechnology
Analytical Chemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1271/bbb.80770

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abstract = "A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.",

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doi = "10.1271/bbb.80770",

language = "English",

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AU - Akamine, Kiichiro

AU - Koyama, Tomoyuki

AU - Yazawa, Kazunaga

PY - 2009

Y1 - 2009

N2 - A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

AB - A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

KW - Anti-androgen effect

KW - Banana peel extract

KW - Inhibitor of 5alpha-reductase

KW - Mice

KW - Suppressive effect on benign prostate hyperplasia

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JO - Bioscience, Biotechnology and Biochemistry

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Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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