Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice

Kiichiro Akamine; Tomoyuki Koyama; Kazunaga Yazawa

doi:10.1271/bbb.80770

Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice

Kiichiro Akamine, Tomoyuki Koyama^*, Kazunaga Yazawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

Original language	English
Pages (from-to)	1911-1914
Number of pages	4
Journal	Bioscience, Biotechnology and Biochemistry
Volume	73
Issue number	9
DOIs	https://doi.org/10.1271/bbb.80770
Publication status	Published - 2009
Externally published	Yes

Keywords

Anti-androgen effect
Banana peel extract
Inhibitor of 5alpha-reductase
Mice
Suppressive effect on benign prostate hyperplasia

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Biology
Applied Microbiology and Biotechnology
Analytical Chemistry
Organic Chemistry

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title = "Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice",

abstract = "A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.",

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AU - Akamine, Kiichiro

AU - Koyama, Tomoyuki

AU - Yazawa, Kazunaga

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Y1 - 2009

N2 - A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

AB - A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-respon- sive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

KW - Anti-androgen effect

KW - Banana peel extract

KW - Inhibitor of 5alpha-reductase

KW - Mice

KW - Suppressive effect on benign prostate hyperplasia

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Banana peel extract suppressed prostate gland enlargement in testosterone-treated mice

Abstract

Keywords

ASJC Scopus subject areas

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