Basal gene expression of vascular endothelial growth factor-related transcriptional factors in rat skeletal muscle differs between slow and fast fiber types

Takeshi Otsuki, Seiji Maeda, Motoyuki Iemitsu, Subrina Jesmin, Takashi Miyauchi

Research output: Contribution to journalArticlepeer-review

Abstract

Skeletal muscle is comprised of multiple fiber types. Slow-twitch oxidative muscle fibers have greater capillary density compared with fast-twitch glycolytic fibers of skeletal muscle. To gain insight into the molecular mechanism underlying the difference of capillary density, we investigated whether the basal gene expression of vascular endothelial growth factor (VEGF), a major angiogenesis-related factor, and its transcriptional factors (hypoxia-inducible factor-1α, transforming growth factor-β1, c-jun, and c-fos) differs between these two fiber types of rat skeletal muscle. The mRNA expression of VEGF and its transcriptional factors was significantly higher in slow type fiber of muscle (soleus muscle) compared with fast type fiber of muscle (plantaris and tibialis anterior muscles). These results suggest that the difference of basal gene expression of VEGF and its transcriptional factors between slow and fast fiber types of skeletal muscle may partly contribute to the difference in capillary density between these two fiber types.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
Journaljapanese journal of physical fitness and sports medicine
Volume55
Issue numberSUPPL.
DOIs
Publication statusPublished - 2006 Oct
Externally publishedYes

Keywords

  • c-fos
  • c-jun
  • Capillary density
  • Hypoxia-inducible factor-1α
  • Transforming growth factor-β1

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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