Basic studies on the effects of stenotic connectors on mechanical blood hemolysis

D. Zhou, H. Fujimasu, A. Nogawa, T. Kijima, Mitsuo Umezu

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    In order to obtain fundamental data on the effects of inner shapes of connectors on blood, in vitro hemolysis tests were performed by using an original designed extracorporeal circuit. Several types of stenotic connectors were made, and each piece was incorporated in each identical circuit. Then, heparinized fresh calf blood was infused into each circuit and was circulated by the centrifugal pump. In this comparative study, changes in plasma free hemoglobin in each circuit were obtained as a function of the pumping time of up to 6 hours. A brief summary of the results are as follows: 1) The connector could achieve a low hemolysis condition if there was an inlet taper of 20 degrees, or a leading edge of only R = 0.5 mm. 2) A suface roughness (Ra) might be a great factor to the hemolysis, because hemolysis level on the Ra of 1.35 μm produced by six times as compared with that on the Ra of 0.54 μm. 3) Even if a connector had an abrupt stenosis with smooth surface (Ra = 0.54 μm), the hemolysis was kept low.

    Original languageEnglish
    Pages (from-to)559-563
    Number of pages5
    JournalJapanese Journal of Artificial Organs
    Volume23
    Issue number3
    Publication statusPublished - 1994

    Fingerprint

    Hemolysis
    Pathologic Constriction
    Hemoglobins

    Keywords

    • flow separation
    • hemolysis
    • plasma free hemoglobin
    • steady flow circuit
    • stenotic tube

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Basic studies on the effects of stenotic connectors on mechanical blood hemolysis. / Zhou, D.; Fujimasu, H.; Nogawa, A.; Kijima, T.; Umezu, Mitsuo.

    In: Japanese Journal of Artificial Organs, Vol. 23, No. 3, 1994, p. 559-563.

    Research output: Contribution to journalArticle

    Zhou, D. ; Fujimasu, H. ; Nogawa, A. ; Kijima, T. ; Umezu, Mitsuo. / Basic studies on the effects of stenotic connectors on mechanical blood hemolysis. In: Japanese Journal of Artificial Organs. 1994 ; Vol. 23, No. 3. pp. 559-563.
    @article{4caf4b7fc0ec4cd68ecde083ff1c6452,
    title = "Basic studies on the effects of stenotic connectors on mechanical blood hemolysis",
    abstract = "In order to obtain fundamental data on the effects of inner shapes of connectors on blood, in vitro hemolysis tests were performed by using an original designed extracorporeal circuit. Several types of stenotic connectors were made, and each piece was incorporated in each identical circuit. Then, heparinized fresh calf blood was infused into each circuit and was circulated by the centrifugal pump. In this comparative study, changes in plasma free hemoglobin in each circuit were obtained as a function of the pumping time of up to 6 hours. A brief summary of the results are as follows: 1) The connector could achieve a low hemolysis condition if there was an inlet taper of 20 degrees, or a leading edge of only R = 0.5 mm. 2) A suface roughness (Ra) might be a great factor to the hemolysis, because hemolysis level on the Ra of 1.35 μm produced by six times as compared with that on the Ra of 0.54 μm. 3) Even if a connector had an abrupt stenosis with smooth surface (Ra = 0.54 μm), the hemolysis was kept low.",
    keywords = "flow separation, hemolysis, plasma free hemoglobin, steady flow circuit, stenotic tube",
    author = "D. Zhou and H. Fujimasu and A. Nogawa and T. Kijima and Mitsuo Umezu",
    year = "1994",
    language = "English",
    volume = "23",
    pages = "559--563",
    journal = "Japanese Journal of Artificial Organs",
    issn = "0300-0818",
    publisher = "Japanese Society for Artificial Organs and Tissues",
    number = "3",

    }

    TY - JOUR

    T1 - Basic studies on the effects of stenotic connectors on mechanical blood hemolysis

    AU - Zhou, D.

    AU - Fujimasu, H.

    AU - Nogawa, A.

    AU - Kijima, T.

    AU - Umezu, Mitsuo

    PY - 1994

    Y1 - 1994

    N2 - In order to obtain fundamental data on the effects of inner shapes of connectors on blood, in vitro hemolysis tests were performed by using an original designed extracorporeal circuit. Several types of stenotic connectors were made, and each piece was incorporated in each identical circuit. Then, heparinized fresh calf blood was infused into each circuit and was circulated by the centrifugal pump. In this comparative study, changes in plasma free hemoglobin in each circuit were obtained as a function of the pumping time of up to 6 hours. A brief summary of the results are as follows: 1) The connector could achieve a low hemolysis condition if there was an inlet taper of 20 degrees, or a leading edge of only R = 0.5 mm. 2) A suface roughness (Ra) might be a great factor to the hemolysis, because hemolysis level on the Ra of 1.35 μm produced by six times as compared with that on the Ra of 0.54 μm. 3) Even if a connector had an abrupt stenosis with smooth surface (Ra = 0.54 μm), the hemolysis was kept low.

    AB - In order to obtain fundamental data on the effects of inner shapes of connectors on blood, in vitro hemolysis tests were performed by using an original designed extracorporeal circuit. Several types of stenotic connectors were made, and each piece was incorporated in each identical circuit. Then, heparinized fresh calf blood was infused into each circuit and was circulated by the centrifugal pump. In this comparative study, changes in plasma free hemoglobin in each circuit were obtained as a function of the pumping time of up to 6 hours. A brief summary of the results are as follows: 1) The connector could achieve a low hemolysis condition if there was an inlet taper of 20 degrees, or a leading edge of only R = 0.5 mm. 2) A suface roughness (Ra) might be a great factor to the hemolysis, because hemolysis level on the Ra of 1.35 μm produced by six times as compared with that on the Ra of 0.54 μm. 3) Even if a connector had an abrupt stenosis with smooth surface (Ra = 0.54 μm), the hemolysis was kept low.

    KW - flow separation

    KW - hemolysis

    KW - plasma free hemoglobin

    KW - steady flow circuit

    KW - stenotic tube

    UR - http://www.scopus.com/inward/record.url?scp=0028241423&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0028241423&partnerID=8YFLogxK

    M3 - Article

    AN - SCOPUS:0028241423

    VL - 23

    SP - 559

    EP - 563

    JO - Japanese Journal of Artificial Organs

    JF - Japanese Journal of Artificial Organs

    SN - 0300-0818

    IS - 3

    ER -