Bayesian estimation of the internal structure of proteins from single-molecule measurements

Makito Miyazaki, Takahiro Harada

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In single-molecule protein experiments, the observable variables are restricted within a small fraction of the entire degrees of freedom. Therefore, to investigate the physical nature of proteins in detail, we always need to estimate the hidden internal structure referring only to the accessible degrees of freedom. We formulate this problem on the basis of Bayesian inference, which can be applied to various complex systems. In the ideal case, we find that in general the framework actually works. Although careful numerical studies confirm that our method outperforms the conventional method by up to two orders of magnitude, we find a striking phenomenon: a loss-of-precision transition occurs abruptly when the design of the observation system is inappropriate. The basic features of the proposed method are illustrated using a simple but nontrivial model.

Original languageEnglish
Article number085108
JournalJournal of Chemical Physics
Volume134
Issue number8
DOIs
Publication statusPublished - 2011 Feb 28
Externally publishedYes

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ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry
  • Medicine(all)

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