TY - JOUR
T1 - Behavioral and Electroencephalographic Effects of Zopiclone, a Cyclopyrrolone Derivative
AU - Ueki, Showa
AU - Watanabe, Shigenori
AU - Yamamoto, Tsuneyuki
AU - Kataoka, Yasufumi
AU - Shibata, Shigenobu
AU - Shibata, Kazuhiko
AU - Ohta, Hisashi
AU - Shimazoe, Takao
AU - Kawamoto, Hirosuke
PY - 1987
Y1 - 1987
N2 - Behavioral effects of zopiclone were investigated in mice and rats and compared with the data on diazepam, nitrazepam and flurazepam. The electro encephalographic effect of the drug was also examined in unanesthetized rabbits with chronic electrode implants and compared with that of diazepam. The present results indicate that zopiclone possesses pharmacological properties qualitatively similar to benzodiazepines, which are characterized by potent anticonflict and antiaggressive effects and much weaker anticonvulsant, muscle relaxant, ataxiogenic, sedative and anesthesia potentiating effects; the properties of this drug were com pared with those of diazepam, nitrazepam and flurazepam. Zopiclone suppressed the EEG arousal responses and inhibited afterdischarges induced by electrical stimulation of the hippocampus and amygdala. The effects of zopiclone on EEG and afterdischarges were approximately 1/10 those of diazepam.
AB - Behavioral effects of zopiclone were investigated in mice and rats and compared with the data on diazepam, nitrazepam and flurazepam. The electro encephalographic effect of the drug was also examined in unanesthetized rabbits with chronic electrode implants and compared with that of diazepam. The present results indicate that zopiclone possesses pharmacological properties qualitatively similar to benzodiazepines, which are characterized by potent anticonflict and antiaggressive effects and much weaker anticonvulsant, muscle relaxant, ataxiogenic, sedative and anesthesia potentiating effects; the properties of this drug were com pared with those of diazepam, nitrazepam and flurazepam. Zopiclone suppressed the EEG arousal responses and inhibited afterdischarges induced by electrical stimulation of the hippocampus and amygdala. The effects of zopiclone on EEG and afterdischarges were approximately 1/10 those of diazepam.
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U2 - 10.1254/jjp.43.309
DO - 10.1254/jjp.43.309
M3 - Article
C2 - 3495682
AN - SCOPUS:0023112951
SN - 0021-5198
VL - 43
SP - 309
EP - 326
JO - Japanese Journal of Pharmacology
JF - Japanese Journal of Pharmacology
IS - 3
ER -