Behavioral and electroencephalographic effects of zopiclone, a cyclopyrrolone derivative

S. Ueki, S. Watanabe, T. Yamamoto, Y. Kataoka, Shigenobu Shibata, K. Shibata, H. Ohta, T. Shimazoe, H. Kawamoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Behavioral effects of zopiclone were investigated in mice and rats and compared with the data on diazepam, nitrazepam and flurazepam. The electroencephalographic effect of the drug was also examined in unanesthetized rabbits with chronic electrode implants and compared with that of diazepam. The present results indicate that zopiclone possesses pharmacological properties qualitatively similar to benzodiazepines, which are characterized by potent anticonflict and antiaggressive effects and much weaker anticonvulsant, muscle relaxant, ataxiogenic, sedative and anesthesia potentiating effects; the properties of this drug were compared with those of diazepam, nitrazepam and flurazepam. Zopiclone suppressed the EEG arousal responses and inhibited afterdischarges induced by electrical stimulation of the hippocampus and amygdala. The effects of zopiclone on EEG and afterdischarges were approximately 1/10 those of diazepam.

Original languageEnglish
Pages (from-to)309-326
Number of pages18
JournalJapanese Journal of Pharmacology
Volume43
Issue number3
Publication statusPublished - 1987
Externally publishedYes

Fingerprint

zopiclone
Diazepam
Flurazepam
Nitrazepam
Electroencephalography
Arousal
Amygdala
Hypnotics and Sedatives
Benzodiazepines
Pharmaceutical Preparations
Anticonvulsants
Electric Stimulation
Hippocampus
Electrodes
Anesthesia
Pharmacology
Rabbits
Muscles

ASJC Scopus subject areas

  • Pharmacology

Cite this

Ueki, S., Watanabe, S., Yamamoto, T., Kataoka, Y., Shibata, S., Shibata, K., ... Kawamoto, H. (1987). Behavioral and electroencephalographic effects of zopiclone, a cyclopyrrolone derivative. Japanese Journal of Pharmacology, 43(3), 309-326.

Behavioral and electroencephalographic effects of zopiclone, a cyclopyrrolone derivative. / Ueki, S.; Watanabe, S.; Yamamoto, T.; Kataoka, Y.; Shibata, Shigenobu; Shibata, K.; Ohta, H.; Shimazoe, T.; Kawamoto, H.

In: Japanese Journal of Pharmacology, Vol. 43, No. 3, 1987, p. 309-326.

Research output: Contribution to journalArticle

Ueki, S, Watanabe, S, Yamamoto, T, Kataoka, Y, Shibata, S, Shibata, K, Ohta, H, Shimazoe, T & Kawamoto, H 1987, 'Behavioral and electroencephalographic effects of zopiclone, a cyclopyrrolone derivative', Japanese Journal of Pharmacology, vol. 43, no. 3, pp. 309-326.
Ueki, S. ; Watanabe, S. ; Yamamoto, T. ; Kataoka, Y. ; Shibata, Shigenobu ; Shibata, K. ; Ohta, H. ; Shimazoe, T. ; Kawamoto, H. / Behavioral and electroencephalographic effects of zopiclone, a cyclopyrrolone derivative. In: Japanese Journal of Pharmacology. 1987 ; Vol. 43, No. 3. pp. 309-326.
@article{1b51de1e4f3f4779aa5d9cf920b31298,
title = "Behavioral and electroencephalographic effects of zopiclone, a cyclopyrrolone derivative",
abstract = "Behavioral effects of zopiclone were investigated in mice and rats and compared with the data on diazepam, nitrazepam and flurazepam. The electroencephalographic effect of the drug was also examined in unanesthetized rabbits with chronic electrode implants and compared with that of diazepam. The present results indicate that zopiclone possesses pharmacological properties qualitatively similar to benzodiazepines, which are characterized by potent anticonflict and antiaggressive effects and much weaker anticonvulsant, muscle relaxant, ataxiogenic, sedative and anesthesia potentiating effects; the properties of this drug were compared with those of diazepam, nitrazepam and flurazepam. Zopiclone suppressed the EEG arousal responses and inhibited afterdischarges induced by electrical stimulation of the hippocampus and amygdala. The effects of zopiclone on EEG and afterdischarges were approximately 1/10 those of diazepam.",
author = "S. Ueki and S. Watanabe and T. Yamamoto and Y. Kataoka and Shigenobu Shibata and K. Shibata and H. Ohta and T. Shimazoe and H. Kawamoto",
year = "1987",
language = "English",
volume = "43",
pages = "309--326",
journal = "Japanese Journal of Pharmacology",
issn = "0021-5198",
publisher = "Japanese Pharmacological Society",
number = "3",

}

TY - JOUR

T1 - Behavioral and electroencephalographic effects of zopiclone, a cyclopyrrolone derivative

AU - Ueki, S.

AU - Watanabe, S.

AU - Yamamoto, T.

AU - Kataoka, Y.

AU - Shibata, Shigenobu

AU - Shibata, K.

AU - Ohta, H.

AU - Shimazoe, T.

AU - Kawamoto, H.

PY - 1987

Y1 - 1987

N2 - Behavioral effects of zopiclone were investigated in mice and rats and compared with the data on diazepam, nitrazepam and flurazepam. The electroencephalographic effect of the drug was also examined in unanesthetized rabbits with chronic electrode implants and compared with that of diazepam. The present results indicate that zopiclone possesses pharmacological properties qualitatively similar to benzodiazepines, which are characterized by potent anticonflict and antiaggressive effects and much weaker anticonvulsant, muscle relaxant, ataxiogenic, sedative and anesthesia potentiating effects; the properties of this drug were compared with those of diazepam, nitrazepam and flurazepam. Zopiclone suppressed the EEG arousal responses and inhibited afterdischarges induced by electrical stimulation of the hippocampus and amygdala. The effects of zopiclone on EEG and afterdischarges were approximately 1/10 those of diazepam.

AB - Behavioral effects of zopiclone were investigated in mice and rats and compared with the data on diazepam, nitrazepam and flurazepam. The electroencephalographic effect of the drug was also examined in unanesthetized rabbits with chronic electrode implants and compared with that of diazepam. The present results indicate that zopiclone possesses pharmacological properties qualitatively similar to benzodiazepines, which are characterized by potent anticonflict and antiaggressive effects and much weaker anticonvulsant, muscle relaxant, ataxiogenic, sedative and anesthesia potentiating effects; the properties of this drug were compared with those of diazepam, nitrazepam and flurazepam. Zopiclone suppressed the EEG arousal responses and inhibited afterdischarges induced by electrical stimulation of the hippocampus and amygdala. The effects of zopiclone on EEG and afterdischarges were approximately 1/10 those of diazepam.

UR - http://www.scopus.com/inward/record.url?scp=0023112951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023112951&partnerID=8YFLogxK

M3 - Article

C2 - 3495682

AN - SCOPUS:0023112951

VL - 43

SP - 309

EP - 326

JO - Japanese Journal of Pharmacology

JF - Japanese Journal of Pharmacology

SN - 0021-5198

IS - 3

ER -