Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative

S. Ueki, S. Watanabe, T. Yamamoto, Shigenobu Shibata, K. Shibata

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The behavioral effect of brotizolam was investigated in mice and rats, in comparison with those of diazepam, nitrazepam and estazolam. Locomotor activity of rats in an open field situation was slightly increased with smaller doses of brotizolam and estazolam and with larger doses of nitrazepam, while it was decreased with large doses of brotizolam and estazolam. The anticonflict effect of brotizolam in rats was approximately as potent as that of diazepam and was augmented following chronic administration for 10 days. In suppressing hyperemotionality and muricide of olfactory bulbectomized rats, brotizolam was more potent than diazepam, being approximately equipotent to nitrazepam and estazolam. Brotizolam, diazepam, nitrazepam and estazolam prevented both maximal electro-shock and pentetrazol convulsions in mice, the effects on the latter being much more potent than those on the former. In impairing rotarod performance, brotizolam was as potent as estazolam and nitrazepam and was much more potent than diazepam in mice, but was less potent than estazolam and nitrazepam in rats. These results indicate that brotizolam possesses pharmacological properties characteristic to benzodiazepines and that the activity is more potent than that of diazepam and approximately as potent as those of nitrazepam and estazolam.

Original languageEnglish
Pages (from-to)287-299
Number of pages13
JournalJapanese Journal of Pharmacology
Volume35
Issue number3
Publication statusPublished - 1984
Externally publishedYes

Fingerprint

brotizolam
Estazolam
Nitrazepam
Diazepam
Locomotion
Benzodiazepines

ASJC Scopus subject areas

  • Pharmacology

Cite this

Ueki, S., Watanabe, S., Yamamoto, T., Shibata, S., & Shibata, K. (1984). Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative. Japanese Journal of Pharmacology, 35(3), 287-299.

Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative. / Ueki, S.; Watanabe, S.; Yamamoto, T.; Shibata, Shigenobu; Shibata, K.

In: Japanese Journal of Pharmacology, Vol. 35, No. 3, 1984, p. 287-299.

Research output: Contribution to journalArticle

Ueki, S, Watanabe, S, Yamamoto, T, Shibata, S & Shibata, K 1984, 'Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative', Japanese Journal of Pharmacology, vol. 35, no. 3, pp. 287-299.
Ueki, S. ; Watanabe, S. ; Yamamoto, T. ; Shibata, Shigenobu ; Shibata, K. / Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative. In: Japanese Journal of Pharmacology. 1984 ; Vol. 35, No. 3. pp. 287-299.
@article{914f341f2e6047c7a4d291d0b140a34f,
title = "Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative",
abstract = "The behavioral effect of brotizolam was investigated in mice and rats, in comparison with those of diazepam, nitrazepam and estazolam. Locomotor activity of rats in an open field situation was slightly increased with smaller doses of brotizolam and estazolam and with larger doses of nitrazepam, while it was decreased with large doses of brotizolam and estazolam. The anticonflict effect of brotizolam in rats was approximately as potent as that of diazepam and was augmented following chronic administration for 10 days. In suppressing hyperemotionality and muricide of olfactory bulbectomized rats, brotizolam was more potent than diazepam, being approximately equipotent to nitrazepam and estazolam. Brotizolam, diazepam, nitrazepam and estazolam prevented both maximal electro-shock and pentetrazol convulsions in mice, the effects on the latter being much more potent than those on the former. In impairing rotarod performance, brotizolam was as potent as estazolam and nitrazepam and was much more potent than diazepam in mice, but was less potent than estazolam and nitrazepam in rats. These results indicate that brotizolam possesses pharmacological properties characteristic to benzodiazepines and that the activity is more potent than that of diazepam and approximately as potent as those of nitrazepam and estazolam.",
author = "S. Ueki and S. Watanabe and T. Yamamoto and Shigenobu Shibata and K. Shibata",
year = "1984",
language = "English",
volume = "35",
pages = "287--299",
journal = "Japanese Journal of Pharmacology",
issn = "0021-5198",
publisher = "Japanese Pharmacological Society",
number = "3",

}

TY - JOUR

T1 - Behavioral effects of brotizolam, a new thienotriazolodiazepine derivative

AU - Ueki, S.

AU - Watanabe, S.

AU - Yamamoto, T.

AU - Shibata, Shigenobu

AU - Shibata, K.

PY - 1984

Y1 - 1984

N2 - The behavioral effect of brotizolam was investigated in mice and rats, in comparison with those of diazepam, nitrazepam and estazolam. Locomotor activity of rats in an open field situation was slightly increased with smaller doses of brotizolam and estazolam and with larger doses of nitrazepam, while it was decreased with large doses of brotizolam and estazolam. The anticonflict effect of brotizolam in rats was approximately as potent as that of diazepam and was augmented following chronic administration for 10 days. In suppressing hyperemotionality and muricide of olfactory bulbectomized rats, brotizolam was more potent than diazepam, being approximately equipotent to nitrazepam and estazolam. Brotizolam, diazepam, nitrazepam and estazolam prevented both maximal electro-shock and pentetrazol convulsions in mice, the effects on the latter being much more potent than those on the former. In impairing rotarod performance, brotizolam was as potent as estazolam and nitrazepam and was much more potent than diazepam in mice, but was less potent than estazolam and nitrazepam in rats. These results indicate that brotizolam possesses pharmacological properties characteristic to benzodiazepines and that the activity is more potent than that of diazepam and approximately as potent as those of nitrazepam and estazolam.

AB - The behavioral effect of brotizolam was investigated in mice and rats, in comparison with those of diazepam, nitrazepam and estazolam. Locomotor activity of rats in an open field situation was slightly increased with smaller doses of brotizolam and estazolam and with larger doses of nitrazepam, while it was decreased with large doses of brotizolam and estazolam. The anticonflict effect of brotizolam in rats was approximately as potent as that of diazepam and was augmented following chronic administration for 10 days. In suppressing hyperemotionality and muricide of olfactory bulbectomized rats, brotizolam was more potent than diazepam, being approximately equipotent to nitrazepam and estazolam. Brotizolam, diazepam, nitrazepam and estazolam prevented both maximal electro-shock and pentetrazol convulsions in mice, the effects on the latter being much more potent than those on the former. In impairing rotarod performance, brotizolam was as potent as estazolam and nitrazepam and was much more potent than diazepam in mice, but was less potent than estazolam and nitrazepam in rats. These results indicate that brotizolam possesses pharmacological properties characteristic to benzodiazepines and that the activity is more potent than that of diazepam and approximately as potent as those of nitrazepam and estazolam.

UR - http://www.scopus.com/inward/record.url?scp=0021257979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021257979&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 287

EP - 299

JO - Japanese Journal of Pharmacology

JF - Japanese Journal of Pharmacology

SN - 0021-5198

IS - 3

ER -