Behavioral effects of quinupramine, a new tricyclic antidepressant

Showa Ueki, Tsuneyuki Yamamoto, Takao Shimazoe, Shigenobu Shibata, Yoshihiro Tani, Koichi Machida, Masakazu Hojo, Yoichi Yoshida, Hiroshi Tatsumi

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of a new tricyclic antidepressant quinupramine (5-(3-quinuclidinyl)-10,11 dihydro-5H-dibenz 〔b, f〕 azepine) on various animal behaviors were examined in mice and rats and compared with those of imipramine, amitriptyline and maprotiline. Quinupramine antagonized haloperidol-induced catalepsy and tetrabenazine-induced ptosis and potentiated methamphetamine- and apomorphine-induced stereotyped behavior. These effects were almost the same as or even more potent than those of imipramine and amitriptyline. Quinupramine decreased locomotor activity in mice, but potentiated methamphetamine induced hyperactivity to a greater degree than imipramine and amitriptyline. On the other hand, quinupramine inhibited muricide in accumbens-lesioned rats, but did not prominently inhibit muricide in olfactory-bulbectomized and raphe-lesioned rats. Quinupramine decreased the duration of immobility in low doses without affecting locomotor activity, and this effect was almost the same as that of imipramine and amitriptyline and more potent than that of maprotiline. Quinupramine antagonized physostigmine lethality and oxotremorine-induced tremor, suggesting that quinupramine has a central anticholinergic action. Quinupramine, like imipramine and amitriptyline, has no effect on conditioned avoidance behavior. In conclusion, quinupramine generally has the same behavioral profile as typical tricyclic antidepressants, but it has somewhat different effects from imipramine and amitriptyline since quinupramine has a potent central anticholinergic and a weak antimuricide effect.

Original languageEnglish
Pages (from-to)359-369
Number of pages11
JournalFolia Pharmacologica Japonica
Volume91
Issue number6
DOIs
Publication statusPublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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