Beyond Axon Guidance: Roles of Slit-Robo Signaling in Neocortical Formation

Yuko Gonda, Takashi Namba, Carina Hanashima

Research output: Contribution to journalReview articlepeer-review

Abstract

The formation of the neocortex relies on intracellular and extracellular signaling molecules that are involved in the sequential steps of corticogenesis, ranging from the proliferation and differentiation of neural progenitor cells to the migration and dendrite formation of neocortical neurons. Abnormalities in these steps lead to disruption of the cortical structure and circuit, and underly various neurodevelopmental diseases, including dyslexia and autism spectrum disorder (ASD). In this review, we focus on the axon guidance signaling Slit-Robo, and address the multifaceted roles of Slit-Robo signaling in neocortical development. Recent studies have clarified the roles of Slit-Robo signaling not only in axon guidance but also in progenitor cell proliferation and migration, and the maturation of neocortical neurons. We further discuss the etiology of neurodevelopmental diseases, which are caused by defects in Slit-Robo signaling during neocortical formation.

Original languageEnglish
Article number607415
JournalFrontiers in Cell and Developmental Biology
Volume8
DOIs
Publication statusPublished - 2020 Dec 23

Keywords

  • axon guidance
  • dendrite
  • migration
  • neocortex
  • proliferation
  • Robo
  • Slit
  • spine

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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