BINAM- mono -PHOS as new entry for multinuclear copper catalysts in asymmetric conjugate addition of organozinc reagents

Kohei Endo, Ryotaro Takayama, Takanori Shibata

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The readily functionalized ligands, BINAM-PHOS, participate in the copper-catalyzed asymmetric conjugate addition of organozinc reagents to enones. The incorporation of benzoyl derivatives on nitrogen atoms was crucial to promote the reaction. Notably, BINAM-PHOS derivatives gave the opposite major enantiomers to that obtained using BINOL-PHOS derivatives, which we have developed for the construction of multinuclear catalysts.

Original languageEnglish
Article numberST-2013-U0225-L
Pages (from-to)1155-1159
Number of pages5
JournalSynlett
Volume24
Issue number9
DOIs
Publication statusPublished - 2013 Apr 25

Keywords

  • addition
  • alkylation
  • asymmetric catalysis
  • copper
  • organometallic reagents

ASJC Scopus subject areas

  • Organic Chemistry

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