Biodegradable and Electroactive TEMPO-Substituted Acrylamide/Lactide Copolymers

Xiuli Zhuang, Han Zhang, Natsuru Chikushi, Changwen Zhao, Kenichi Oyaizu, Xuesi Chen, Hiroyuki Nishide

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14 Citations (Scopus)

Abstract

Copolymers composed of PLA and PTAm were prepared by a macromonomer approach. The PLA bearing vinyl group at chain end was copolymerized with 2,2,6,6-tetrametylpiperidine-4-ylacrylamide. The resulted copolymers were oxidized by a peroxide to give PTAm-g-PLA. The structures of the copolymers were confirmed by NMR and FTIR spectroscopy. The comparison of 1H NMR results and SQUID measurements demonstrated that the oxidation of the PTAm fragment proceeded almost to completion. An MTT assay, cell adhesion and spreading evaluation showed that the copolymers exhibited improved cytocompatibility as compared to the PTAm homopolymer due to the introduction of the biocompatible PLA moiety.Novel PTAm-g-PLA copolymers were successfully prepared by a PLA macromonomer approach. The obtained copolymer contained stable radical units which was biologically active. MTT assay and cell adhesion and spreading evaluation showed that the copolymers exhibited improved cytocompatibility as compared to the PTAm homopolymer due to the introduction of the biocompatible PLA moiety. The copolymers are expected to have promising applications in tissue engineering.

Original languageEnglish
Pages (from-to)1203-1209
Number of pages7
JournalMacromolecular Bioscience
Volume10
Issue number10
DOIs
Publication statusPublished - 2010 Oct 1

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Keywords

  • Biodegradable
  • Copolymers
  • Macromonomers
  • Polylactide
  • Radical polymers

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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