Biodegradable and Electroactive TEMPO-Substituted Acrylamide/Lactide Copolymers

Xiuli Zhuang, Han Zhang, Natsuru Chikushi, Changwen Zhao, Kenichi Oyaizu, Xuesi Chen, Hiroyuki Nishide

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Copolymers composed of PLA and PTAm were prepared by a macromonomer approach. The PLA bearing vinyl group at chain end was copolymerized with 2,2,6,6-tetrametylpiperidine-4-ylacrylamide. The resulted copolymers were oxidized by a peroxide to give PTAm-g-PLA. The structures of the copolymers were confirmed by NMR and FTIR spectroscopy. The comparison of 1H NMR results and SQUID measurements demonstrated that the oxidation of the PTAm fragment proceeded almost to completion. An MTT assay, cell adhesion and spreading evaluation showed that the copolymers exhibited improved cytocompatibility as compared to the PTAm homopolymer due to the introduction of the biocompatible PLA moiety.Novel PTAm-g-PLA copolymers were successfully prepared by a PLA macromonomer approach. The obtained copolymer contained stable radical units which was biologically active. MTT assay and cell adhesion and spreading evaluation showed that the copolymers exhibited improved cytocompatibility as compared to the PTAm homopolymer due to the introduction of the biocompatible PLA moiety. The copolymers are expected to have promising applications in tissue engineering.

Original languageEnglish
Pages (from-to)1203-1209
Number of pages7
JournalMacromolecular Bioscience
Volume10
Issue number10
DOIs
Publication statusPublished - 2010 Oct

Fingerprint

Acrylamide
Cell Adhesion
Copolymers
Peroxides
Fourier Transform Infrared Spectroscopy
Tissue Engineering
Magnetic Resonance Spectroscopy
Cell adhesion
Homopolymerization
Assays
Bearings (structural)
Nuclear magnetic resonance
TEMPO
dilactide
SQUIDs
Tissue engineering
Spectroscopy
Oxidation
Proton Magnetic Resonance Spectroscopy

Keywords

  • Biodegradable
  • Copolymers
  • Macromonomers
  • Polylactide
  • Radical polymers

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Biodegradable and Electroactive TEMPO-Substituted Acrylamide/Lactide Copolymers. / Zhuang, Xiuli; Zhang, Han; Chikushi, Natsuru; Zhao, Changwen; Oyaizu, Kenichi; Chen, Xuesi; Nishide, Hiroyuki.

In: Macromolecular Bioscience, Vol. 10, No. 10, 10.2010, p. 1203-1209.

Research output: Contribution to journalArticle

Zhuang, Xiuli ; Zhang, Han ; Chikushi, Natsuru ; Zhao, Changwen ; Oyaizu, Kenichi ; Chen, Xuesi ; Nishide, Hiroyuki. / Biodegradable and Electroactive TEMPO-Substituted Acrylamide/Lactide Copolymers. In: Macromolecular Bioscience. 2010 ; Vol. 10, No. 10. pp. 1203-1209.
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