Bioengineering of bacterial magnetic particles and their applications in biotechnology

Tomoko Yoshino, Yoshiaki Maeda, Tadashi Matsunaga

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Magnetic particles have attracted much attention for their versatile uses in biotechnology, especially in medical applications. The major advantage of magnetic particles is that they can be easily manipulated by magnetic forces. Mag-netotactic bacteria synthesize nano-sized biomagnetites, otherwise known as bacterial magnetic particles (BacMPs) that are individually enveloped by a lipid bilayer membrane. The mechanisms of BacMP synthesis have been analyzed by ge-nomic, proteomic, and bioinformatic approaches. Based on those studies in Magnetospirillum magneticum AMB-1, functional nanomaterials have been designed and produced. Through genetic engineering, functional proteins such as enzymes, antibodies, and receptors have been successfully displayed on BacMPs. These functional BacMPs have been utilized in various biosensors and bio-separation processes. Here, recent papers and patents for bioengineering of BacMPs and their applications in biotechnology are reviewed. The elucidation of the mechanism of magnetic particle synthesis has provided a roadmap for the design of novel biomaterials that can play useful roles in multiple disciplinary fields.

Original languageEnglish
Pages (from-to)214-225
Number of pages12
JournalRecent Patents on Biotechnology
Volume4
Issue number3
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Bioengineering
Biotechnology
Magnetospirillum
Genetic engineering
Lipid bilayers
Genetic Engineering
Patents
Nanostructures
Lipid Bilayers
Biocompatible Materials
Biosensing Techniques
Medical applications
Bioinformatics
Membrane Lipids
Computational Biology
Nanostructured materials
Biosensors
Antibodies
Biomaterials
Proteomics

Keywords

  • Anchor
  • Automated system
  • Bacteria
  • Bio-separation
  • Biosensors
  • Display
  • Gene fusion
  • Magnetic particles
  • Protein engineering

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Bioengineering

Cite this

Bioengineering of bacterial magnetic particles and their applications in biotechnology. / Yoshino, Tomoko; Maeda, Yoshiaki; Matsunaga, Tadashi.

In: Recent Patents on Biotechnology, Vol. 4, No. 3, 2010, p. 214-225.

Research output: Contribution to journalArticle

@article{7d3ca5512d974a3aa2e88264557d02eb,
title = "Bioengineering of bacterial magnetic particles and their applications in biotechnology",
abstract = "Magnetic particles have attracted much attention for their versatile uses in biotechnology, especially in medical applications. The major advantage of magnetic particles is that they can be easily manipulated by magnetic forces. Mag-netotactic bacteria synthesize nano-sized biomagnetites, otherwise known as bacterial magnetic particles (BacMPs) that are individually enveloped by a lipid bilayer membrane. The mechanisms of BacMP synthesis have been analyzed by ge-nomic, proteomic, and bioinformatic approaches. Based on those studies in Magnetospirillum magneticum AMB-1, functional nanomaterials have been designed and produced. Through genetic engineering, functional proteins such as enzymes, antibodies, and receptors have been successfully displayed on BacMPs. These functional BacMPs have been utilized in various biosensors and bio-separation processes. Here, recent papers and patents for bioengineering of BacMPs and their applications in biotechnology are reviewed. The elucidation of the mechanism of magnetic particle synthesis has provided a roadmap for the design of novel biomaterials that can play useful roles in multiple disciplinary fields.",
keywords = "Anchor, Automated system, Bacteria, Bio-separation, Biosensors, Display, Gene fusion, Magnetic particles, Protein engineering",
author = "Tomoko Yoshino and Yoshiaki Maeda and Tadashi Matsunaga",
year = "2010",
doi = "10.2174/187220810793611455",
language = "English",
volume = "4",
pages = "214--225",
journal = "Recent Patents on Biotechnology",
issn = "1872-2083",
publisher = "Bentham Science Publishers B.V.",
number = "3",

}

TY - JOUR

T1 - Bioengineering of bacterial magnetic particles and their applications in biotechnology

AU - Yoshino, Tomoko

AU - Maeda, Yoshiaki

AU - Matsunaga, Tadashi

PY - 2010

Y1 - 2010

N2 - Magnetic particles have attracted much attention for their versatile uses in biotechnology, especially in medical applications. The major advantage of magnetic particles is that they can be easily manipulated by magnetic forces. Mag-netotactic bacteria synthesize nano-sized biomagnetites, otherwise known as bacterial magnetic particles (BacMPs) that are individually enveloped by a lipid bilayer membrane. The mechanisms of BacMP synthesis have been analyzed by ge-nomic, proteomic, and bioinformatic approaches. Based on those studies in Magnetospirillum magneticum AMB-1, functional nanomaterials have been designed and produced. Through genetic engineering, functional proteins such as enzymes, antibodies, and receptors have been successfully displayed on BacMPs. These functional BacMPs have been utilized in various biosensors and bio-separation processes. Here, recent papers and patents for bioengineering of BacMPs and their applications in biotechnology are reviewed. The elucidation of the mechanism of magnetic particle synthesis has provided a roadmap for the design of novel biomaterials that can play useful roles in multiple disciplinary fields.

AB - Magnetic particles have attracted much attention for their versatile uses in biotechnology, especially in medical applications. The major advantage of magnetic particles is that they can be easily manipulated by magnetic forces. Mag-netotactic bacteria synthesize nano-sized biomagnetites, otherwise known as bacterial magnetic particles (BacMPs) that are individually enveloped by a lipid bilayer membrane. The mechanisms of BacMP synthesis have been analyzed by ge-nomic, proteomic, and bioinformatic approaches. Based on those studies in Magnetospirillum magneticum AMB-1, functional nanomaterials have been designed and produced. Through genetic engineering, functional proteins such as enzymes, antibodies, and receptors have been successfully displayed on BacMPs. These functional BacMPs have been utilized in various biosensors and bio-separation processes. Here, recent papers and patents for bioengineering of BacMPs and their applications in biotechnology are reviewed. The elucidation of the mechanism of magnetic particle synthesis has provided a roadmap for the design of novel biomaterials that can play useful roles in multiple disciplinary fields.

KW - Anchor

KW - Automated system

KW - Bacteria

KW - Bio-separation

KW - Biosensors

KW - Display

KW - Gene fusion

KW - Magnetic particles

KW - Protein engineering

UR - http://www.scopus.com/inward/record.url?scp=78649993678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649993678&partnerID=8YFLogxK

U2 - 10.2174/187220810793611455

DO - 10.2174/187220810793611455

M3 - Article

VL - 4

SP - 214

EP - 225

JO - Recent Patents on Biotechnology

JF - Recent Patents on Biotechnology

SN - 1872-2083

IS - 3

ER -