Biological rhythms and drugs

    Research output: Contribution to journalArticle

    Abstract

    Precise, rhythmic, daily change of the internal milieu is a conspicuous feature of all living organisms. It affects the temporal patterns of all kinds of behaviors during a day and deeply influences both the social structure and daily life of individual human beings. These daily variations arise from the internal circadian mechanisms. Three functions of the endogenous clock are discriminated; rhythm generation, entrainment to light- dark cycle and output from the clock. The endogenous clock is localized in the suprachiasmatic nucleus in mammals. Interestingly, recent papers demonstrated the widespread expression (hippocampus, cerebellum and also peripheral body) of clock genes such as mPer1 and mPer2 (homologs of the Dorsophila period gene). In this review, I describe the cellular mechanisms of circadian oscillation, entrainment and output. Serotonergic drugs and melatonin affect the light and non light-induced entrainment, and lithium and estrogen change the oscillation. Thus drugs can regulate the circadian oscillation, entrainment and outputs. Therefore, I mention the possibility that CNS drugs are useful to keep physiological homeostasis through their action on biological rhythms.

    Original languageEnglish
    Pages (from-to)11-20
    Number of pages10
    JournalJapanese Journal of Psychopharmacology
    Volume19
    Issue number1
    Publication statusPublished - 1999

    Fingerprint

    Periodicity
    Serotonin Agents
    Light
    Suprachiasmatic Nucleus
    Photoperiod
    Melatonin
    Lithium
    Pharmaceutical Preparations
    Cerebellum
    Genes
    Mammals
    Hippocampus
    Estrogens
    Homeostasis

    Keywords

    • Circadian
    • Clock gene
    • Drugs
    • Suprachiasmatic

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Pharmacology (medical)
    • Pharmacology, Toxicology and Pharmaceutics(all)

    Cite this

    Biological rhythms and drugs. / Shibata, Shigenobu.

    In: Japanese Journal of Psychopharmacology, Vol. 19, No. 1, 1999, p. 11-20.

    Research output: Contribution to journalArticle

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