Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting: Expert Review Document on Techniques and Clinical Implementation

Antonios P. Antoniadis, Peter Mortier, Ghassan Kassab, Gabriele Dubini, Nicolas Foin, Yoshinobu Murasato, Andreas A. Giannopoulos, Shengxian Tu, Kiyotaka Iwasaki, Yutaka Hikichi, Francesco Migliavacca, Claudio Chiastra, Jolanda J. Wentzel, Frank Gijsen, Johan H C Reiber, Peter Barlis, Patrick W. Serruys, Deepak L. Bhatt, Goran Stankovic, Elazer R. EdelmanGeorge D. Giannoglou, Yves Louvard, Yiannis S. Chatzizisis

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Abstract

    Treatment of coronary bifurcation lesions remains an ongoing challenge for interventional cardiologists. Stenting of coronary bifurcations carries higher risk for in-stent restenosis, stent thrombosis, and recurrent clinical events. This review summarizes the current evidence regarding application and use of biomechanical modeling in the study of stent properties, local flow dynamics, and outcomes after percutaneous coronary interventions in bifurcation lesions. Biomechanical modeling of bifurcation stenting involves computational simulations and in vitro bench testing using subject-specific arterial geometries obtained from in vivo imaging. Biomechanical modeling has the potential to optimize stenting strategies and stent design, thereby reducing adverse outcomes. Large-scale clinical studies are needed to establish the translation of pre-clinical findings to the clinical arena.

    Original languageEnglish
    Article number2103
    Pages (from-to)1281-1296
    Number of pages16
    JournalJACC: Cardiovascular Interventions
    Volume8
    Issue number10
    DOIs
    Publication statusPublished - 2015 Aug 24

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    Keywords

    • bifurcation
    • biomechanical stress
    • coronary artery disease
    • endothelial shear stress
    • stent(s)

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Antoniadis, A. P., Mortier, P., Kassab, G., Dubini, G., Foin, N., Murasato, Y., Giannopoulos, A. A., Tu, S., Iwasaki, K., Hikichi, Y., Migliavacca, F., Chiastra, C., Wentzel, J. J., Gijsen, F., Reiber, J. H. C., Barlis, P., Serruys, P. W., Bhatt, D. L., Stankovic, G., ... Chatzizisis, Y. S. (2015). Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting: Expert Review Document on Techniques and Clinical Implementation. JACC: Cardiovascular Interventions, 8(10), 1281-1296. [2103]. https://doi.org/10.1016/j.jcin.2015.06.015