Biomolecular sensors utilizing waveguide modes excited by evanescent fields

M. Fujimaki, C. Rockstuhl, X. Wang, K. Awazu, J. Tominaga, T. Ikeda, Y. Koganezawa, Yoshimichi Ohki

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Abstract

    Properties of evanescent-field-coupled waveguide-mode sensors consisting of a multi-layer structure made of a SiO2 waveguide, a thin metal layer (Au, Cu, W or Ti), and a high refractive index glass substrate illuminated under the Kretschmann configuration have been theoretically and experimentally investigated. In all cases, reflectivity changes attributed to streptavidin combining to biotinyl groups were observed in close spectral vicinity of the waveguide resonances. The sensors with the Au and the Cu layers show superior sensitivity as compared to those with the W and the Ti layers, whereas the W and Ti layers show better thermal and chemical stability. The results indicate that the materials of thin metal layers should be chosen in accordance with the purpose of sensors and/or environment in which the sensors are used.

    Original languageEnglish
    Pages (from-to)320-326
    Number of pages7
    JournalJournal of Microscopy
    Volume229
    Issue number2
    DOIs
    Publication statusPublished - 2008 Feb

    Fingerprint

    Evanescent fields
    Waveguides
    Metals
    waveguides
    Refractometry
    Streptavidin
    sensors
    Sensors
    Glass
    Hot Temperature
    Chemical stability
    Refractive index
    Thermodynamic stability
    metals
    laminates
    thermal stability
    refractivity
    reflectance
    Substrates
    glass

    Keywords

    • Evanescent field
    • Reflecting film
    • Sensor
    • Waveguide mode

    ASJC Scopus subject areas

    • Instrumentation

    Cite this

    Biomolecular sensors utilizing waveguide modes excited by evanescent fields. / Fujimaki, M.; Rockstuhl, C.; Wang, X.; Awazu, K.; Tominaga, J.; Ikeda, T.; Koganezawa, Y.; Ohki, Yoshimichi.

    In: Journal of Microscopy, Vol. 229, No. 2, 02.2008, p. 320-326.

    Research output: Contribution to journalArticle

    Fujimaki, M, Rockstuhl, C, Wang, X, Awazu, K, Tominaga, J, Ikeda, T, Koganezawa, Y & Ohki, Y 2008, 'Biomolecular sensors utilizing waveguide modes excited by evanescent fields', Journal of Microscopy, vol. 229, no. 2, pp. 320-326. https://doi.org/10.1111/j.1365-2818.2008.01907.x
    Fujimaki M, Rockstuhl C, Wang X, Awazu K, Tominaga J, Ikeda T et al. Biomolecular sensors utilizing waveguide modes excited by evanescent fields. Journal of Microscopy. 2008 Feb;229(2):320-326. https://doi.org/10.1111/j.1365-2818.2008.01907.x
    Fujimaki, M. ; Rockstuhl, C. ; Wang, X. ; Awazu, K. ; Tominaga, J. ; Ikeda, T. ; Koganezawa, Y. ; Ohki, Yoshimichi. / Biomolecular sensors utilizing waveguide modes excited by evanescent fields. In: Journal of Microscopy. 2008 ; Vol. 229, No. 2. pp. 320-326.
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    AU - Tominaga, J.

    AU - Ikeda, T.

    AU - Koganezawa, Y.

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