Biosensing by optical waveguide spectroscopy based on localized surface plasmon resonance of gold nanoparticles used as a probe or as a label

Mayuki Kajiura, Takuya Nakanishi, Hironori Iida, Harumi Takada, Tetsuya Osaka

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

The application of localized surface plasmon resonance (LSPR) of gold nanoparticles for the detection of biotin-streptavidin binding, as a typical biological reaction, was investigated by using optical waveguide spectroscopy, and two different modes for the use of gold nanoparticles, one as a probe and the other as a label were compared with each other. The combination with optical waveguide spectroscopy was found to bring about a high sensitivity for the biomolecular detection system using LSPR of gold nanoparticles in both modes. In particular, the mode using gold nanoparticles as a label was demonstrated to be of advantage to devising proper procedures for using nanoparticles and evaluating actual response relevant to the phenomenon concerned, and thus to sensitive detection.

Original languageEnglish
Pages (from-to)140-145
Number of pages6
JournalJournal of Colloid And Interface Science
Volume335
Issue number1
DOIs
Publication statusPublished - 2009 Jul 1

Keywords

  • Biotin-streptavidin reaction
  • Gold nanoparticle
  • Localized surface plasmon resonance
  • Optical waveguide spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

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