Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94

Sho Kato, Takayuki Motoyama, Yushi Futamura, Masakazu Uramoto, Toshihiko Nogawa, Toshiaki Hayashi, Hiroshi Hirota, Akira Tanaka, Naoko Takahashi-Ando, Takashi Kamakura, Hiroyuki Osada*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

8 Citations (Scopus)

Abstract

We identified the biosynthetic gene cluster for lucilactaene, a cell cycle inhibitor from a filamentous fungus Fusarium sp. RK 97–94. The luc1 knockout strain accumulated demethylated analogs, indicating the involvement of Luc1 methyltransferase in lucilactaene biosynthesis. Lucilactaene showed potent antimalarial activity. Our data suggested that methylation and ether ring formation are essential for its potent antimalarial activity.

Original languageEnglish
Pages (from-to)1303-1307
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume84
Issue number6
DOIs
Publication statusPublished - 2020 Jun 2
Externally publishedYes

Keywords

  • biological activity
  • biosynthesis
  • malaria
  • Natural products
  • PKS-NRPS

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94'. Together they form a unique fingerprint.

Cite this