Birth and death of genes linked to chromosomal inversion

Yoshikazu Furuta, Mikihiko Kawai, Koji Yahara, Noriko Takahashi, Naofumi Handa, Takeshi Tsuru, Kenshiro Oshima, Masaru Yoshida, Takeshi Azuma, Masahira Hattori, Ikuo Uchiyama, Ichizo Kobayashi

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The birth and death of genes is central to adaptive evolution, yet the underlying genome dynamics remain elusive. The availability of closely related complete genome sequences helps to follow changes in gene contents and clarify their relationship to overall genome organization. Helicobacter pylori, bacteria in our stomach, are known for their extreme genome plasticity through mutation and recombination and will make a good target for such an analysis. In comparing their complete genome sequences, we found that gain and loss of genes (loci) for outer membrane proteins, which mediate host interaction, occurred at breakpoints of chromosomal inversions. Sequence comparison there revealed a unique mechanism of DNA duplication: DNA duplication associated with inversion. In this process, a DNA segment at one chromosomal locus is copied and inserted, in an inverted orientation, into a distant locus on the same chromosome, while the entire region between these two loci is also inverted. Recognition of this and three more inversion modes, which occur through reciprocal recombination between long or short sequence similarity or adjacent to a mobile element, allowed reconstruction of synteny evolution through inversion events in this species. These results will guide the interpretation of extensive DNA sequencing results for understanding long- and short-term genome evolution in various organisms and in cancer cells.

Original languageEnglish
Pages (from-to)1501-1506
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume108
Issue number4
DOIs
Publication statusPublished - 2011 Jan 25
Externally publishedYes

Fingerprint

Parturition
Genome
Genes
Genetic Recombination
DNA
Synteny
DNA Sequence Analysis
Helicobacter pylori
Stomach
Membrane Proteins
Chromosomes
Bacteria
Mutation
Neoplasms

Keywords

  • Gene duplication
  • Genome comparison
  • Genome rearrangement
  • Replicative inversion
  • Structural variation

ASJC Scopus subject areas

  • General

Cite this

Furuta, Y., Kawai, M., Yahara, K., Takahashi, N., Handa, N., Tsuru, T., ... Kobayashi, I. (2011). Birth and death of genes linked to chromosomal inversion. Proceedings of the National Academy of Sciences of the United States of America, 108(4), 1501-1506. https://doi.org/10.1073/pnas.1012579108

Birth and death of genes linked to chromosomal inversion. / Furuta, Yoshikazu; Kawai, Mikihiko; Yahara, Koji; Takahashi, Noriko; Handa, Naofumi; Tsuru, Takeshi; Oshima, Kenshiro; Yoshida, Masaru; Azuma, Takeshi; Hattori, Masahira; Uchiyama, Ikuo; Kobayashi, Ichizo.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, No. 4, 25.01.2011, p. 1501-1506.

Research output: Contribution to journalArticle

Furuta, Y, Kawai, M, Yahara, K, Takahashi, N, Handa, N, Tsuru, T, Oshima, K, Yoshida, M, Azuma, T, Hattori, M, Uchiyama, I & Kobayashi, I 2011, 'Birth and death of genes linked to chromosomal inversion', Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 4, pp. 1501-1506. https://doi.org/10.1073/pnas.1012579108
Furuta, Yoshikazu ; Kawai, Mikihiko ; Yahara, Koji ; Takahashi, Noriko ; Handa, Naofumi ; Tsuru, Takeshi ; Oshima, Kenshiro ; Yoshida, Masaru ; Azuma, Takeshi ; Hattori, Masahira ; Uchiyama, Ikuo ; Kobayashi, Ichizo. / Birth and death of genes linked to chromosomal inversion. In: Proceedings of the National Academy of Sciences of the United States of America. 2011 ; Vol. 108, No. 4. pp. 1501-1506.
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