Bisoxazolomycin A: A new natural product from 'Streptomyces subflavus subsp. irumaensis' AM-3603

Wilaiwan Koomsiri, Yuki Inahashi, Toru Kimura, Kazuro Shiomi, Yoko Takahashi, Satoshi Omura, Arinthip Thamchaipenet, Takuji Nakashima

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Bisoxazolomycin (1), oxazolomycin A2 (2) and oxazolomycin A (3) were identified by physicochemical screening approach from a culture broth of 'Streptomyces subflavus subsp. irumaensis' AM-3603. Compound 2 is a hydrolyzed analog of 3 at the β-lactone ring, and 1 is a new dimeric analog of 2. Compounds 1 and 2 exhibited less potent antibacterial activity and cytotoxicity than 3, which might be due to lack of the β-lactone ring.

Original languageEnglish
Pages (from-to)1142-1145
Number of pages4
JournalJournal of Antibiotics
Volume70
Issue number12
DOIs
Publication statusPublished - 2017 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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