Blood flow responses in celiac and superior mesenteric arteries in the initial phase of digestion

Nami Someya, Masako Yamaoka Endo, Yoshiyuki Fukuba, Naoyuki Hayashi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Blood flow (BF) responses in the celiac artery (CA) and superior mesenteric artery (SMA) during and immediately after a meal are poorly understood. We characterized postprandial BF responses in these arteries in the initial phase of digestion. After a baseline measurement in the overnight fasting state, healthy subjects ingested solid food (300 kcal) and water ad libitum within 5 min (4.6 ± 0.2 min, means ± SE), and then rested for 60 min in the postprandial state. Mean blood velocities (MBVs) in CA (n = 7) and SMA (n = 9) and mean arterial pressure (MAP) were measured throughout the procedure. The MAP was divided by the MBV to yield the resistance index (RI). The MBV in CA and SMA started increasing within a minute after beginning the meal. The MBV in CA rapidly reached its peak increase (60 ± 8% change from baseline) at 5 ± 1 min after the start of the meal, whereas the MBV in SMA gradually reached its peak increase (134 ± 14%) at 41 ± 4 min after the start of the meal, reflecting a decrease in the RI for both CA and SMA. These findings suggested an earlier increase in CA and SMA MBV, implying that the increase of BF in some parts of the small intestine precedes the arrival of chyme.

Original languageEnglish
Pages (from-to)R1790-R1796
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume294
Issue number6
DOIs
Publication statusPublished - 2008 Jun
Externally publishedYes

Keywords

  • Food intake
  • Postprandial splanchnic hyperemia
  • Visceral artery

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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