BLOOD INTERFACE WITH SEGMENTED POLYURETHANES

'MULTILAYERED PROTEIN PASSIVATION MECHANISM'.

T. Matsuda, H. Takano, K. Hayashi, Y. Taenaka, S. Takaichi, Mitsuo Umezu, T. Nakamura, H. Iwata, T. Nakatani, T. Tanaka, S. Takatani, T. Akutsu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

38 Citations (Scopus)

Abstract

Although protein adsorption is the first event when blood comes in contact with foreign surfaces, adsorbed proteins would be expected to be reoriented or denatured in a time-lapse process. In addition, the protein layer formed must be reorganized via dynamic exchange with circulating plasma proteins during long-term implantation. It is not exactly known how antithrombogenicity is acquired and what mechanism dominates especially for long-term implantation. In the study reported here; detailed analyses of segmented polyurethane surfaces implanted for weeks to months are presented with the aid of modern microscopic and spectroscopic instruments. Based on experimental observations, 'multilayered proteinaceous passivation', which is quite contrary to the early albumin monolayer passivation hypothesis, is a newly proposed and conceptualized theory for long-term antithrombogenicity.

Original languageEnglish
Title of host publicationTransactions - American Society for Artificial Internal Organs
Pages353-358
Number of pages6
Volume30
Publication statusPublished - 1984
Externally publishedYes

Fingerprint

Polyurethanes
Passivation
Blood
Proteins
Adsorption
Blood Proteins
Albumins
Membrane Proteins
Monolayers
Plasmas

ASJC Scopus subject areas

  • Engineering(all)
  • Medicine(all)

Cite this

Matsuda, T., Takano, H., Hayashi, K., Taenaka, Y., Takaichi, S., Umezu, M., ... Akutsu, T. (1984). BLOOD INTERFACE WITH SEGMENTED POLYURETHANES: 'MULTILAYERED PROTEIN PASSIVATION MECHANISM'. In Transactions - American Society for Artificial Internal Organs (Vol. 30, pp. 353-358)

BLOOD INTERFACE WITH SEGMENTED POLYURETHANES : 'MULTILAYERED PROTEIN PASSIVATION MECHANISM'. / Matsuda, T.; Takano, H.; Hayashi, K.; Taenaka, Y.; Takaichi, S.; Umezu, Mitsuo; Nakamura, T.; Iwata, H.; Nakatani, T.; Tanaka, T.; Takatani, S.; Akutsu, T.

Transactions - American Society for Artificial Internal Organs. Vol. 30 1984. p. 353-358.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Matsuda, T, Takano, H, Hayashi, K, Taenaka, Y, Takaichi, S, Umezu, M, Nakamura, T, Iwata, H, Nakatani, T, Tanaka, T, Takatani, S & Akutsu, T 1984, BLOOD INTERFACE WITH SEGMENTED POLYURETHANES: 'MULTILAYERED PROTEIN PASSIVATION MECHANISM'. in Transactions - American Society for Artificial Internal Organs. vol. 30, pp. 353-358.
Matsuda T, Takano H, Hayashi K, Taenaka Y, Takaichi S, Umezu M et al. BLOOD INTERFACE WITH SEGMENTED POLYURETHANES: 'MULTILAYERED PROTEIN PASSIVATION MECHANISM'. In Transactions - American Society for Artificial Internal Organs. Vol. 30. 1984. p. 353-358
Matsuda, T. ; Takano, H. ; Hayashi, K. ; Taenaka, Y. ; Takaichi, S. ; Umezu, Mitsuo ; Nakamura, T. ; Iwata, H. ; Nakatani, T. ; Tanaka, T. ; Takatani, S. ; Akutsu, T. / BLOOD INTERFACE WITH SEGMENTED POLYURETHANES : 'MULTILAYERED PROTEIN PASSIVATION MECHANISM'. Transactions - American Society for Artificial Internal Organs. Vol. 30 1984. pp. 353-358
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