Body temperature and its effect on leukocyte mobilization, cytokines and markers of neutrophil activation during and after exercise

Jonathan Peake, Jeremiah J. Peiffer, Chris R. Abbiss, Kazunori Nosaka, Mitsuharu Okutsu, Paul B. Laursen, Katsuhiko Suzuki

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Weinvestigated the influence of rectal temperature on the immune system during and after exercise. Ten welltrained male cyclists completed exercise trials (90 min cycling at 60% VO 2max + 16.1 - km time trial) on three separate occasions: once in 18°C and twice in 32°C. Twenty minutes after the trials in 32°C, the cyclists sat for ∼20 min in cold water (14°C) on one occasion, whereas on another occasion they sat at room temperature. Rectal temperature increased significantly during cycling in both conditions, and was significantly higher after cycling in 32°C than in 18°C (P<0.05). Leukocyte counts increased significantly during cycling but did not differ between the conditions. The concentrations of serum interleukin (IL)-6, IL-8 and IL-10, plasma catecholamines, granulocyte-colony stimulating factor, myeloperoxidase and calprotectin increased significantly following cycling in both conditions. The concentrations of serum IL-8 (25%), IL-10 (120%), IL-1 receptor antagonist (70%), tumour necrosis factor-a (17%), plasma myeloperoxidase (26%) and norepinephrine (130%) were significantly higher after cycling in 32°C than in 18°C. During recovery from exercise in 32°C, rectal temperature was significantly lower in response to sitting in cold water than at room temperature. However, immune changes during 90 min of recovery did not differ significantly between sitting in cold water and at room temperature. The greater rise in rectal temperature during exercise in 32°C increased the concentrations of serum IL-8, IL-10, IL-1ra, TNF-α and plasma myeloperoxidase, whereas the greater decline in rectal temperature during cold water immersion after exercise did not affect immune responses.

Original languageEnglish
Pages (from-to)391-401
Number of pages11
JournalEuropean Journal of Applied Physiology
Volume102
Issue number4
DOIs
Publication statusPublished - 2008 Mar

Fingerprint

Neutrophil Activation
Body Temperature
Leukocytes
Cytokines
Temperature
Interleukin-8
Interleukin-10
Peroxidase
Water
Serum
Leukocyte L1 Antigen Complex
Interleukin-1 Receptors
Interleukin-17
Interleukins
Immersion
Granulocyte Colony-Stimulating Factor
Leukocyte Count
Catecholamines
Immune System
Interleukin-6

Keywords

  • Cold water immersion
  • Cytokines
  • Exercise
  • Hyperthermia
  • Stress hormones

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Orthopedics and Sports Medicine
  • Physiology (medical)
  • Physiology
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Body temperature and its effect on leukocyte mobilization, cytokines and markers of neutrophil activation during and after exercise. / Peake, Jonathan; Peiffer, Jeremiah J.; Abbiss, Chris R.; Nosaka, Kazunori; Okutsu, Mitsuharu; Laursen, Paul B.; Suzuki, Katsuhiko.

In: European Journal of Applied Physiology, Vol. 102, No. 4, 03.2008, p. 391-401.

Research output: Contribution to journalArticle

Peake, Jonathan ; Peiffer, Jeremiah J. ; Abbiss, Chris R. ; Nosaka, Kazunori ; Okutsu, Mitsuharu ; Laursen, Paul B. ; Suzuki, Katsuhiko. / Body temperature and its effect on leukocyte mobilization, cytokines and markers of neutrophil activation during and after exercise. In: European Journal of Applied Physiology. 2008 ; Vol. 102, No. 4. pp. 391-401.
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