Boron nitride nanotubes: A novel vector for targeted magnetic drug delivery

Gianni Ciofani, Vittoria Raffa, Jun Yu, Ying Chen, Yosuke Obata, Shinji Takeoka, Arianna Menciassi, Alfred Cuschieri

    Research output: Contribution to journalArticle

    59 Citations (Scopus)

    Abstract

    Whereas several biomedical applications of carbon nanotubes have been proposed, the use of boron nitride nanotubes (BNNTs) in this field has been largely unexplored despite their unique and potentially useful properties. Our group has recently initiated an experimental program aimed at the exploration of the interactions between BNNTs and living cells. In the present paper, we report on the magnetic properties of BNNTs containing Fe catalysts which confirm the feasibility for their use as nanovectors for targeted drug delivery. The magnetisation curves of BNNTs characterised by the present study are typical of superparamagnetic materials with important parameters, including magnetic permeability and magnetic momentum, derived by employing Langevin theory. In-vitro tests have demonstrated the feasibility for influencing the uptake of BNNTs by living cells by exposure to an external magnetic source. A finite element method analysis devised to predict this effect produced predictive data with close agreement with the experimental observations.

    Original languageEnglish
    Pages (from-to)33-38
    Number of pages6
    JournalCurrent Nanoscience
    Volume5
    Issue number1
    DOIs
    Publication statusPublished - 2009

    Fingerprint

    Nanotubes
    Boron nitride
    Drug delivery
    Pharmaceutical Preparations
    Cells
    Magnetic permeability
    Finite Element Analysis
    Carbon Nanotubes
    Permeability
    Carbon nanotubes
    Magnetization
    Magnetic properties
    Momentum
    boron nitride
    Finite element method
    Catalysts

    Keywords

    • Boron nitride nanotubes
    • Magnetism
    • Modelling of uptake kinetics
    • Targeted drug delivery

    ASJC Scopus subject areas

    • Biotechnology
    • Bioengineering
    • Biomedical Engineering
    • Medicine (miscellaneous)
    • Pharmaceutical Science

    Cite this

    Boron nitride nanotubes : A novel vector for targeted magnetic drug delivery. / Ciofani, Gianni; Raffa, Vittoria; Yu, Jun; Chen, Ying; Obata, Yosuke; Takeoka, Shinji; Menciassi, Arianna; Cuschieri, Alfred.

    In: Current Nanoscience, Vol. 5, No. 1, 2009, p. 33-38.

    Research output: Contribution to journalArticle

    Ciofani, G, Raffa, V, Yu, J, Chen, Y, Obata, Y, Takeoka, S, Menciassi, A & Cuschieri, A 2009, 'Boron nitride nanotubes: A novel vector for targeted magnetic drug delivery', Current Nanoscience, vol. 5, no. 1, pp. 33-38. https://doi.org/10.2174/157341309787314557
    Ciofani, Gianni ; Raffa, Vittoria ; Yu, Jun ; Chen, Ying ; Obata, Yosuke ; Takeoka, Shinji ; Menciassi, Arianna ; Cuschieri, Alfred. / Boron nitride nanotubes : A novel vector for targeted magnetic drug delivery. In: Current Nanoscience. 2009 ; Vol. 5, No. 1. pp. 33-38.
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