Brain activation during whole body cooling in humans studied with functional magnetic resonance imaging

Kazuyuki Kanosue; Norihiro Sadato; Tomohisa Okada; Tamae Yoda; Sadamu Nakai; Kyoko Yoshida; Takayoshi Hosono; Kei Nagashima; Tomoko Yagishita; Osamu Inoue; Kaoru Kobayashi; Yoshiharu Yonekura

doi:10.1016/S0304-3940(02)00621-3

Brain activation during whole body cooling in humans studied with functional magnetic resonance imaging

Kazuyuki Kanosue^*, Norihiro Sadato, Tomohisa Okada, Tamae Yoda, Sadamu Nakai, Kyoko Yoshida, Takayoshi Hosono, Kei Nagashima, Tomoko Yagishita, Osamu Inoue, Kaoru Kobayashi, Yoshiharu Yonekura

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Regional activation of the brain was studied in humans using functional magnetic resonance imaging during whole body cooling that produced thermal comfort/discomfort. Eight normal male subjects lay in a sleeping bag through which air was blown, exposing subjects to cold air (8°C) for 22 min. Each subject scored their degree of thermal comfort and discomfort every min. As the subjects reported more discomfort the blood oxygen level dependent response in the bilateral amygdala increased. There was no activation in the thalamus, somatosensory, cingulate, or insula cortices. This result suggests that the amygdala plays a role in the genesis of thermal discomfort due to cold.

Original language	English
Pages (from-to)	157-160
Number of pages	4
Journal	Neuroscience Letters
Volume	329
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(02)00621-3
Publication status	Published - 2002 Aug 30
Externally published	Yes

Keywords

Amygdala
Comfort and discomfort
Functional magnetic resonance imaging
Human
Whole body cooling

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(02)00621-3

Cite this

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title = "Brain activation during whole body cooling in humans studied with functional magnetic resonance imaging",

abstract = "Regional activation of the brain was studied in humans using functional magnetic resonance imaging during whole body cooling that produced thermal comfort/discomfort. Eight normal male subjects lay in a sleeping bag through which air was blown, exposing subjects to cold air (8°C) for 22 min. Each subject scored their degree of thermal comfort and discomfort every min. As the subjects reported more discomfort the blood oxygen level dependent response in the bilateral amygdala increased. There was no activation in the thalamus, somatosensory, cingulate, or insula cortices. This result suggests that the amygdala plays a role in the genesis of thermal discomfort due to cold.",

keywords = "Amygdala, Comfort and discomfort, Functional magnetic resonance imaging, Human, Whole body cooling",

author = "Kazuyuki Kanosue and Norihiro Sadato and Tomohisa Okada and Tamae Yoda and Sadamu Nakai and Kyoko Yoshida and Takayoshi Hosono and Kei Nagashima and Tomoko Yagishita and Osamu Inoue and Kaoru Kobayashi and Yoshiharu Yonekura",

note = "Funding Information: This study was supported in part by by NISSAN SCIENCE FOUNDATION, a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (No. 11557003), and a research grant from {\textquoteleft}Research for the Future{\textquoteright} Program of the Japan Society for the Promotion of Science (JSPS-RFLF97L00203).",

year = "2002",

month = aug,

day = "30",

doi = "10.1016/S0304-3940(02)00621-3",

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T1 - Brain activation during whole body cooling in humans studied with functional magnetic resonance imaging

AU - Kanosue, Kazuyuki

AU - Sadato, Norihiro

AU - Okada, Tomohisa

AU - Yoda, Tamae

AU - Nakai, Sadamu

AU - Yoshida, Kyoko

AU - Hosono, Takayoshi

AU - Nagashima, Kei

AU - Yagishita, Tomoko

AU - Inoue, Osamu

AU - Kobayashi, Kaoru

AU - Yonekura, Yoshiharu

N1 - Funding Information: This study was supported in part by by NISSAN SCIENCE FOUNDATION, a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (No. 11557003), and a research grant from ‘Research for the Future’ Program of the Japan Society for the Promotion of Science (JSPS-RFLF97L00203).

PY - 2002/8/30

Y1 - 2002/8/30

N2 - Regional activation of the brain was studied in humans using functional magnetic resonance imaging during whole body cooling that produced thermal comfort/discomfort. Eight normal male subjects lay in a sleeping bag through which air was blown, exposing subjects to cold air (8°C) for 22 min. Each subject scored their degree of thermal comfort and discomfort every min. As the subjects reported more discomfort the blood oxygen level dependent response in the bilateral amygdala increased. There was no activation in the thalamus, somatosensory, cingulate, or insula cortices. This result suggests that the amygdala plays a role in the genesis of thermal discomfort due to cold.

AB - Regional activation of the brain was studied in humans using functional magnetic resonance imaging during whole body cooling that produced thermal comfort/discomfort. Eight normal male subjects lay in a sleeping bag through which air was blown, exposing subjects to cold air (8°C) for 22 min. Each subject scored their degree of thermal comfort and discomfort every min. As the subjects reported more discomfort the blood oxygen level dependent response in the bilateral amygdala increased. There was no activation in the thalamus, somatosensory, cingulate, or insula cortices. This result suggests that the amygdala plays a role in the genesis of thermal discomfort due to cold.

KW - Amygdala

KW - Comfort and discomfort

KW - Functional magnetic resonance imaging

KW - Human

KW - Whole body cooling

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Brain activation during whole body cooling in humans studied with functional magnetic resonance imaging

Abstract

Keywords

ASJC Scopus subject areas

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