Brain activation during whole body cooling in humans studied with functional magnetic resonance imaging

Kazuyuki Kanosue, Norihiro Sadato, Tomohisa Okada, Tamae Yoda, Sadamu Nakai, Kyoko Yoshida, Takayoshi Hosono, Kei Nagashima, Tomoko Yagishita, Osamu Inoue, Kaoru Kobayashi, Yoshiharu Yonekura

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Regional activation of the brain was studied in humans using functional magnetic resonance imaging during whole body cooling that produced thermal comfort/discomfort. Eight normal male subjects lay in a sleeping bag through which air was blown, exposing subjects to cold air (8°C) for 22 min. Each subject scored their degree of thermal comfort and discomfort every min. As the subjects reported more discomfort the blood oxygen level dependent response in the bilateral amygdala increased. There was no activation in the thalamus, somatosensory, cingulate, or insula cortices. This result suggests that the amygdala plays a role in the genesis of thermal discomfort due to cold.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalNeuroscience Letters
Volume329
Issue number2
DOIs
Publication statusPublished - 2002 Aug 30
Externally publishedYes

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Hot Temperature
Magnetic Resonance Imaging
Amygdala
Brain
Air
Thalamus
Oxygen

Keywords

  • Amygdala
  • Comfort and discomfort
  • Functional magnetic resonance imaging
  • Human
  • Whole body cooling

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Brain activation during whole body cooling in humans studied with functional magnetic resonance imaging. / Kanosue, Kazuyuki; Sadato, Norihiro; Okada, Tomohisa; Yoda, Tamae; Nakai, Sadamu; Yoshida, Kyoko; Hosono, Takayoshi; Nagashima, Kei; Yagishita, Tomoko; Inoue, Osamu; Kobayashi, Kaoru; Yonekura, Yoshiharu.

In: Neuroscience Letters, Vol. 329, No. 2, 30.08.2002, p. 157-160.

Research output: Contribution to journalArticle

Kanosue, K, Sadato, N, Okada, T, Yoda, T, Nakai, S, Yoshida, K, Hosono, T, Nagashima, K, Yagishita, T, Inoue, O, Kobayashi, K & Yonekura, Y 2002, 'Brain activation during whole body cooling in humans studied with functional magnetic resonance imaging', Neuroscience Letters, vol. 329, no. 2, pp. 157-160. https://doi.org/10.1016/S0304-3940(02)00621-3
Kanosue, Kazuyuki ; Sadato, Norihiro ; Okada, Tomohisa ; Yoda, Tamae ; Nakai, Sadamu ; Yoshida, Kyoko ; Hosono, Takayoshi ; Nagashima, Kei ; Yagishita, Tomoko ; Inoue, Osamu ; Kobayashi, Kaoru ; Yonekura, Yoshiharu. / Brain activation during whole body cooling in humans studied with functional magnetic resonance imaging. In: Neuroscience Letters. 2002 ; Vol. 329, No. 2. pp. 157-160.
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