Brain regions expressing Fos during thermoregulatory behavior in rats

Megumi Maruyama, Maiko Nishi, Masahiro Konishi, Yuko Takashige, Kei Nagashima, Toshikazu Kiyohara, Kazuyuki Kanosue

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We surveyed the neural substrata for behavioral thermoregulation with immunohistochemical analysis of the expression of Fos protein in the rat brain. We used an operant system in which a rat exposed to heat (40°C) could get cold air (0°C) for 30 s when it moved into the reward area. Rats moved in and out of the reward area of the system periodically and thus maintained their body temperature at a normal level. In the rats performing heat escape behavior (active group), strong Fos immunoreactivity (Fos-IR) was found in the median preoptic nucleus (MnPO), parastrial nucleus (PS), and dorsomedial hypothalamus (DMH) compared with the controls. Another group of rats (passive group) were given the same temperature changes, regardless of the rat's movement, as those obtained by rats of the active group. Fos-IR in the MnPO was also seen in this group. The present results suggest that the PS and DMH play an important role in the genesis of thermoregulatory behavior, whereas the MnPO may be important for detecting changes in ambient and/or body temperatures.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume285
Issue number5 54-5
Publication statusPublished - 2003 Nov

Fingerprint

Brain
Preoptic Area
Mediodorsal Thalamic Nucleus
Body Temperature
Reward
Hypothalamus
Hot Temperature
Body Temperature Regulation
Air
Temperature
Proteins

Keywords

  • Dorsomedial hypothalamus
  • Operant behavior
  • Preoptic area

ASJC Scopus subject areas

  • Physiology

Cite this

Brain regions expressing Fos during thermoregulatory behavior in rats. / Maruyama, Megumi; Nishi, Maiko; Konishi, Masahiro; Takashige, Yuko; Nagashima, Kei; Kiyohara, Toshikazu; Kanosue, Kazuyuki.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 285, No. 5 54-5, 11.2003.

Research output: Contribution to journalArticle

Maruyama, Megumi ; Nishi, Maiko ; Konishi, Masahiro ; Takashige, Yuko ; Nagashima, Kei ; Kiyohara, Toshikazu ; Kanosue, Kazuyuki. / Brain regions expressing Fos during thermoregulatory behavior in rats. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2003 ; Vol. 285, No. 5 54-5.
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