Caffeine suppresses high-fat diet-induced body weight gain in mice depending on feeding timing

Atsushi Haraguchi, Tomohiro Yamazaki, Conn Ryan, Kaede Ito, Shuhei Sato, Konomi Tamura, Masataka Sekiguchi, Siyuan Cao, Shigenobu Shibata*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The time-dependent effects of caffeine intake on physiological functions remain to be investigated, although various effects of caffeine on physiological functions have been document. Therefore, the present study investigated the optimal timing of caffeine intake to produce an efficient anti-obesity effect. We prepared a high-fat diet (HFD) or HFD supplemented with 0.03% caffeine (HFD-caf) and regulated twice-daily 8-hour time-restricted feeding. Male Institute of Cancer Research mice were divided into three groups: group fed HFD alone (control), group fed HFD-caf at the beginning of the active period (BF-caf), and group fed HFD-caf at the end of the active period (DN-caf). The BF-caf group (42.8 ± 1.5 g) showed lower body weight than the other groups (control, 49.7 ± 2.1 g; DN-caf, 47.1 ± 1.3 g), although the three groups showed similar HFD intake levels. Therefore, caffeine intake at the beginning of the active period suppressed HFD-induced body weight gain.

Original languageEnglish
Article number105307
JournalJournal of Functional Foods
Volume99
DOIs
Publication statusPublished - 2022 Dec

Keywords

  • Anti-obesity effect
  • Caffeine
  • Chrono-nutrition
  • Circadian clock system
  • Lipogenesis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Nutrition and Dietetics

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