Calcium Metabolism, Serum Thyroid-Stimulating Hormone, Prolactin, and Growth Hormone in Spontaneously Hypercholesterolemic Rats

Kunio Shiota, Michio Takahashi, Tsuneo Masaki, Katsuichi Sudo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We have shown previously that spontaneously hypercholesterolemic (SHC) rats exhibit abnormal bone metabolism with advanced bone resorption, which develops with age. In this study, we measured serum levels of growth hormone, thyroid-stimulating hormone, and prolactin in addition to several parameters of calcium metabolism and renal function in young (6-week) and old (24-week) SHC rats and compared these with age-matched Sprague-Dawley rats. In young SHC rats, urinary excretion of hydroxyproline and serum levels of calcium were significantly elevated and excretion of protein into urine and urea nitrogen in the serum were normal, suggesting that calcium metabolism was abnormal without kidney dysfunction at this age. Serum growth hormone and thyroid-stimulating hormone levels were markedly higher (20- to 30-fold and 4- to 5-fold, respectively) in young and old SHC rats, whereas serum prolactin levels were similar. A high level of serum thyroid-stimulating hormone was associated with elevated levels of thyroxine and triiodothyronine in young SHC rats, but not old ones. These results demonstrate that the rat exhibits abnormalities in endocrine function as well as calcium metabolism preceding the occurrence of renal dysfunction.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume190
Issue number3
DOIs
Publication statusPublished - 1989
Externally publishedYes

Fingerprint

Thyrotropin
Metabolism
Prolactin
Growth Hormone
Rats
Calcium
Serum
Kidney
Bone
Hydroxyproline
Triiodothyronine
Bone Resorption
Thyroxine
Sprague Dawley Rats
Urea
Nitrogen
Urine
Bone and Bones
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Calcium Metabolism, Serum Thyroid-Stimulating Hormone, Prolactin, and Growth Hormone in Spontaneously Hypercholesterolemic Rats. / Shiota, Kunio; Takahashi, Michio; Masaki, Tsuneo; Sudo, Katsuichi.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 190, No. 3, 1989, p. 229-233.

Research output: Contribution to journalArticle

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