Calibration system for pulse spectrophotometry using a double-layer pulsation flow-cell

M. Oura, N. Kobayashi, S. Yamamori, S. Takeda, Kiyotaka Iwasaki, Mitsuo Umezu

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    2 Citations (Scopus)

    Abstract

    We have studied noninvasive devices for measuring total hemoglobin and hemoglobin derivatives such as carboxyhemoglobin (COHb) and methemoglobin (MetHb). A calibration procedure needs to be developed to evaluate or calibrate these devices and pulse oximeters for clinical practice. However, people and animals are sometimes exposed to risk when they are used for calibration. In this paper, we propose a new in vitro calibration system for a pulse photometer. This system has a novel double-layer pulsation flow-cell that incorporates both venous and arterial blood flow. Using the calibration system, we are able to measure the in vitro pulsatile optical density ratio (Φvt). The measured Φvt agrees well with the in vivo pulsatile optical density ratio (Φvi). This system simulates an in vivo environment with high accuracy and enables safe calibration. Consequently, the calibration system is able to standardize the performance and accuracy of pulse photometry.

    Original languageEnglish
    Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
    Pages896-899
    Number of pages4
    DOIs
    Publication statusPublished - 2009
    Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN
    Duration: 2009 Sep 22009 Sep 6

    Other

    Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
    CityMinneapolis, MN
    Period09/9/209/9/6

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    ASJC Scopus subject areas

    • Cell Biology
    • Developmental Biology
    • Biomedical Engineering
    • Medicine(all)

    Cite this

    Oura, M., Kobayashi, N., Yamamori, S., Takeda, S., Iwasaki, K., & Umezu, M. (2009). Calibration system for pulse spectrophotometry using a double-layer pulsation flow-cell. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 896-899). [5334889] https://doi.org/10.1109/IEMBS.2009.5334889