Calicheamicin θ 1I: A Rationally Designed Molecule with Extremely Potent and Selective DNA Cleaving Properties and Apoptosis Inducing Activity

K. C. Nicolaou, T. Li, Masahisa Nakada, Conrad W. Hummel, A. Hiatt, W. Wrasidlo

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The attack of a thiolate ion on the trisulfide unit of natural calicheamicin γ I1 (1) activates it to form a diradical, which then attacks DNA. Thioacetate 2 is even more readily activated—under mildly basic conditions caused by OH ions—and likewise exhibits extremely interesting biological properties. (Figure Presented.)

Original languageEnglish
Pages (from-to)183-186
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume33
Issue number2
DOIs
Publication statusPublished - 1994 Feb 1
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Calicheamicin θ 1I: A Rationally Designed Molecule with Extremely Potent and Selective DNA Cleaving Properties and Apoptosis Inducing Activity'. Together they form a unique fingerprint.

  • Cite this