Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata

Masaki Fujita, Youichi Nakao, Shigeki Matsunaga, Rob W M Van Soest, Yoshifumi Itoh, Motoharu Seiki, Nobuhiro Fusetani

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C24 acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC50 of 15.0 μg/mL.

Original languageEnglish
Pages (from-to)569-571
Number of pages3
JournalJournal of Natural Products
Volume66
Issue number4
DOIs
Publication statusPublished - 2003 Apr 1
Externally publishedYes

Fingerprint

Callyspongia
interstitial collagenase
Matrix Metalloproteinase 14
Matrix Metalloproteinase Inhibitors
Porifera
sulfates
Inhibitory Concentration 50
inhibitory concentration 50
Fatty Acids
fatty acids
callysponginol sulfate A
methodology

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata. / Fujita, Masaki; Nakao, Youichi; Matsunaga, Shigeki; Van Soest, Rob W M; Itoh, Yoshifumi; Seiki, Motoharu; Fusetani, Nobuhiro.

In: Journal of Natural Products, Vol. 66, No. 4, 01.04.2003, p. 569-571.

Research output: Contribution to journalArticle

Fujita, M, Nakao, Y, Matsunaga, S, Van Soest, RWM, Itoh, Y, Seiki, M & Fusetani, N 2003, 'Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata', Journal of Natural Products, vol. 66, no. 4, pp. 569-571. https://doi.org/10.1021/np020572s
Fujita, Masaki ; Nakao, Youichi ; Matsunaga, Shigeki ; Van Soest, Rob W M ; Itoh, Yoshifumi ; Seiki, Motoharu ; Fusetani, Nobuhiro. / Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata. In: Journal of Natural Products. 2003 ; Vol. 66, No. 4. pp. 569-571.
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