Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata

Masaki Fujita, Youichi Nakao, Shigeki Matsunaga, Rob W M Van Soest, Yoshifumi Itoh, Motoharu Seiki, Nobuhiro Fusetani

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Abstract

Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C24 acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC50 of 15.0 μg/mL.

Original languageEnglish
Pages (from-to)569-571
Number of pages3
JournalJournal of Natural Products
Volume66
Issue number4
DOIs
Publication statusPublished - 2003 Apr 1
Externally publishedYes

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ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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