Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata

Masaki Fujita, Yoichi Nakao, Shigeki Matsunaga, Rob W.M. Van Soest, Yoshifumi Itoh, Motoharu Seiki, Nobuhiro Fusetani

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C24 acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC50 of 15.0 μg/mL.

Original languageEnglish
Pages (from-to)569-571
Number of pages3
JournalJournal of Natural Products
Volume66
Issue number4
DOIs
Publication statusPublished - 2003 Apr 1
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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