Calyceramides A-C: Neuraminidase inhibitory sulfated ceramides from the marine sponge Discodermia calyx

Yoichi Nakao, Kentaro Takada, Shigeki Matsunaga, Nobuhiro Fusetani

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Three new sulfated ceramides, calyceramides A-C (1-3) were isolated as inhibitors of neuraminidase from the marine sponge Discodermia calyx. Their structures were determined by spectroscopic and chemical methods. The ceramides inhibited neuraminidase with IC50 values of 0.2-0.8 μg mL-1.

Original languageEnglish
Pages (from-to)3013-3017
Number of pages5
JournalTetrahedron
Volume57
Issue number15
DOIs
Publication statusPublished - 2001 Apr 9
Externally publishedYes

Keywords

  • Biologically active compounds
  • Enzyme inhibitors
  • Marine metabolites
  • Sponges

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Calyceramides A-C: Neuraminidase inhibitory sulfated ceramides from the marine sponge Discodermia calyx'. Together they form a unique fingerprint.

  • Cite this