Calyceramides A-C

Neuraminidase inhibitory sulfated ceramides from the marine sponge Discodermia calyx

Youichi Nakao, Kentaro Takada, Shigeki Matsunaga, Nobuhiro Fusetani

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Three new sulfated ceramides, calyceramides A-C (1-3) were isolated as inhibitors of neuraminidase from the marine sponge Discodermia calyx. Their structures were determined by spectroscopic and chemical methods. The ceramides inhibited neuraminidase with IC50 values of 0.2-0.8 μg mL-1.

Original languageEnglish
Pages (from-to)3013-3017
Number of pages5
JournalTetrahedron
Volume57
Issue number15
DOIs
Publication statusPublished - 2001 Apr 9
Externally publishedYes

Fingerprint

Ceramides
Neuraminidase
Porifera
Inhibitory Concentration 50

Keywords

  • Biologically active compounds
  • Enzyme inhibitors
  • Marine metabolites
  • Sponges

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Calyceramides A-C : Neuraminidase inhibitory sulfated ceramides from the marine sponge Discodermia calyx. / Nakao, Youichi; Takada, Kentaro; Matsunaga, Shigeki; Fusetani, Nobuhiro.

In: Tetrahedron, Vol. 57, No. 15, 09.04.2001, p. 3013-3017.

Research output: Contribution to journalArticle

Nakao, Youichi ; Takada, Kentaro ; Matsunaga, Shigeki ; Fusetani, Nobuhiro. / Calyceramides A-C : Neuraminidase inhibitory sulfated ceramides from the marine sponge Discodermia calyx. In: Tetrahedron. 2001 ; Vol. 57, No. 15. pp. 3013-3017.
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