Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters

Kenward K.H. Vong, Kazuki Tsubokura, Youichi Nakao, Tomonori Tanei, Shinzaburo Noguchi, Shinobu Kitazume, Naoyuki Taniguchi, Katsunori Tanaka

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    3 Citations (Scopus)

    Abstract

    Rapidly growing cancer cells have increased levels of intracellular polyamines compared to normal, healthy tissues. Based on the selective reactivity of glycine propargyl esters, probes were synthesized that show evidence for selective polyamine reactivity, which was then applied for selective cancer cell imaging studies.

    Original languageEnglish
    Pages (from-to)8403-8406
    Number of pages4
    JournalChemical Communications
    Volume53
    Issue number60
    DOIs
    Publication statusPublished - 2017

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    ASJC Scopus subject areas

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry

    Cite this

    Vong, K. K. H., Tsubokura, K., Nakao, Y., Tanei, T., Noguchi, S., Kitazume, S., Taniguchi, N., & Tanaka, K. (2017). Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters. Chemical Communications, 53(60), 8403-8406. https://doi.org/10.1039/c7cc01934c