Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters

Kenward K.H. Vong, Kazuki Tsubokura, Yoichi Nakao, Tomonori Tanei, Shinzaburo Noguchi, Shinobu Kitazume, Naoyuki Taniguchi, Katsunori Tanaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Rapidly growing cancer cells have increased levels of intracellular polyamines compared to normal, healthy tissues. Based on the selective reactivity of glycine propargyl esters, probes were synthesized that show evidence for selective polyamine reactivity, which was then applied for selective cancer cell imaging studies.

Original languageEnglish
Pages (from-to)8403-8406
Number of pages4
JournalChemical Communications
Volume53
Issue number60
DOIs
Publication statusPublished - 2017

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Vong, K. K. H., Tsubokura, K., Nakao, Y., Tanei, T., Noguchi, S., Kitazume, S., Taniguchi, N., & Tanaka, K. (2017). Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters. Chemical Communications, 53(60), 8403-8406. https://doi.org/10.1039/c7cc01934c