Abstract
Highly sensitive and selective detection of morphine is exhibited using a capacitive transducer coated with cathodically electropolymerized and molecularly imprinted poly(p aminostyrene). Through molecular imprinting, morphine-specific recognition sites have been fabricated throughout the film, which shows exceptional binding activity toward morphine based from electrochemical capacitance measurements. The thin film sensor has a linear response to morphine solutions with 20–40 × 10−6 m concentrations and a detection limit of 5.95 × 10−6 m. It demonstrates high selectivity toward morphine as compared to other analog molecules including nicotine and cholesterol. The formation of the polymer film is facilitated and monitored using electrochemical-quartz crystal microbalance and characterized by X-ray photoelectron spectroscopy. Infrared spectroscopy confirms the loading and removal of the analyte from the film. Based on molecular modeling calculations, strong hydrogen-bonding interactions between the monomer, cross-linker, and analyte form a stable pre-polymerization complex, which is critical in successfully imprinting morphine into the film and effective sensing of the analyte. (Figure presented.).
| Original language | English |
|---|---|
| Pages (from-to) | 1810-1822 |
| Number of pages | 13 |
| Journal | Macromolecular Chemistry and Physics |
| Volume | 217 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - 2016 Aug 1 |
| Externally published | Yes |
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Keywords
- capacitive detection
- electropolymerization
- molecular imprinting
- morphine
- p-aminostyrene
ASJC Scopus subject areas
- Condensed Matter Physics
- Physical and Theoretical Chemistry
- Polymers and Plastics
- Organic Chemistry
- Materials Chemistry
Cite this
Capacitive Detection of Morphine via Cathodically Electropolymerized, Molecularly Imprinted Poly(p-aminostyrene) Films. / Vergara, Aileen V.; Pernites, Roderick B.; Tiu, Brylee David B.; de Leon, Al Christopher C.; Mangadlao, Joey D.; Binag, Christina A.; Advincula, Rigoberto C.
In: Macromolecular Chemistry and Physics, Vol. 217, No. 16, 01.08.2016, p. 1810-1822.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Capacitive Detection of Morphine via Cathodically Electropolymerized, Molecularly Imprinted Poly(p-aminostyrene) Films
AU - Vergara, Aileen V.
AU - Pernites, Roderick B.
AU - Tiu, Brylee David B.
AU - de Leon, Al Christopher C.
AU - Mangadlao, Joey D.
AU - Binag, Christina A.
AU - Advincula, Rigoberto C.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Highly sensitive and selective detection of morphine is exhibited using a capacitive transducer coated with cathodically electropolymerized and molecularly imprinted poly(p aminostyrene). Through molecular imprinting, morphine-specific recognition sites have been fabricated throughout the film, which shows exceptional binding activity toward morphine based from electrochemical capacitance measurements. The thin film sensor has a linear response to morphine solutions with 20–40 × 10−6 m concentrations and a detection limit of 5.95 × 10−6 m. It demonstrates high selectivity toward morphine as compared to other analog molecules including nicotine and cholesterol. The formation of the polymer film is facilitated and monitored using electrochemical-quartz crystal microbalance and characterized by X-ray photoelectron spectroscopy. Infrared spectroscopy confirms the loading and removal of the analyte from the film. Based on molecular modeling calculations, strong hydrogen-bonding interactions between the monomer, cross-linker, and analyte form a stable pre-polymerization complex, which is critical in successfully imprinting morphine into the film and effective sensing of the analyte. (Figure presented.).
AB - Highly sensitive and selective detection of morphine is exhibited using a capacitive transducer coated with cathodically electropolymerized and molecularly imprinted poly(p aminostyrene). Through molecular imprinting, morphine-specific recognition sites have been fabricated throughout the film, which shows exceptional binding activity toward morphine based from electrochemical capacitance measurements. The thin film sensor has a linear response to morphine solutions with 20–40 × 10−6 m concentrations and a detection limit of 5.95 × 10−6 m. It demonstrates high selectivity toward morphine as compared to other analog molecules including nicotine and cholesterol. The formation of the polymer film is facilitated and monitored using electrochemical-quartz crystal microbalance and characterized by X-ray photoelectron spectroscopy. Infrared spectroscopy confirms the loading and removal of the analyte from the film. Based on molecular modeling calculations, strong hydrogen-bonding interactions between the monomer, cross-linker, and analyte form a stable pre-polymerization complex, which is critical in successfully imprinting morphine into the film and effective sensing of the analyte. (Figure presented.).
KW - capacitive detection
KW - electropolymerization
KW - molecular imprinting
KW - morphine
KW - p-aminostyrene
UR - http://www.scopus.com/inward/record.url?scp=84978280586&partnerID=8YFLogxK
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U2 - 10.1002/macp.201600127
DO - 10.1002/macp.201600127
M3 - Article
VL - 217
SP - 1810
EP - 1822
JO - Macromolecular Chemistry and Physics
JF - Macromolecular Chemistry and Physics
SN - 1022-1352
IS - 16
ER -