Carbon Nanotubes-Hydroxyapatite Nanocomposites for an Improved Osteoblast Cell Response

Sabrina Constanda, Miruna Silvia Stan, Carmen Steluţa Ciobanu, Mikael Motelica-Heino, Regis Guegan, Khalid Lafdi, Anca Dinischiotu, Daniela Predoi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

An alternative and simple coprecipitation method was developed to obtain carbon nanotube-hydroxyapatite (CNTs:HAp) based nanocomposites. The incorporation of CNTs (in a concentration of 5% and 10% of total weight of the nanocomposite) and their impact on both structural and biological properties were studied by using a set of standard complementary biological, microscopic, and spectroscopic techniques. The characteristic peaks of carbon structure in CNTs were not observed in the CNTs-HAp composites by X-ray diffraction analysis. Moreover, FTIR and Raman spectroscopies confirmed the presence of HAp as the main phase of the synthesized CNTs:HAp nanocomposites. The addition of CNTs considerably affected the nanocomposite morphology by increasing the average crystallite size from 18.7 nm (for raw HAp) to 28.6 nm (for CNTs:HAp-10), confirming their proper incorporation. The biocompatibility evaluation of CNTs:HAp-5 and CNTs:HAp-10 nanocomposites included the assessment of several parameters, such as cell viability, antioxidant response, and lipid peroxidation, on human G-292 osteoblast cell line. Our findings revealed good biocompatibility properties for CNTs:HAp nanocomposites prepared by the coprecipitation method supporting their potential uses in orthopedics and prosthetics.

Original languageEnglish
Article number3941501
JournalJournal of Nanomaterials
Volume2016
DOIs
Publication statusPublished - 2016 Jan 1
Externally publishedYes

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Carbon Nanotubes
Osteoblasts
Durapatite
Hydroxyapatite
Carbon nanotubes
Nanocomposites
Coprecipitation
Biocompatibility
Cells
Orthopedics
Crystallite size
Prosthetics
Antioxidants
X ray diffraction analysis
Lipids
Raman spectroscopy
Carbon
Composite materials

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Constanda, S., Stan, M. S., Ciobanu, C. S., Motelica-Heino, M., Guegan, R., Lafdi, K., ... Predoi, D. (2016). Carbon Nanotubes-Hydroxyapatite Nanocomposites for an Improved Osteoblast Cell Response. Journal of Nanomaterials, 2016, [3941501]. https://doi.org/10.1155/2016/3941501

Carbon Nanotubes-Hydroxyapatite Nanocomposites for an Improved Osteoblast Cell Response. / Constanda, Sabrina; Stan, Miruna Silvia; Ciobanu, Carmen Steluţa; Motelica-Heino, Mikael; Guegan, Regis; Lafdi, Khalid; Dinischiotu, Anca; Predoi, Daniela.

In: Journal of Nanomaterials, Vol. 2016, 3941501, 01.01.2016.

Research output: Contribution to journalArticle

Constanda, S, Stan, MS, Ciobanu, CS, Motelica-Heino, M, Guegan, R, Lafdi, K, Dinischiotu, A & Predoi, D 2016, 'Carbon Nanotubes-Hydroxyapatite Nanocomposites for an Improved Osteoblast Cell Response', Journal of Nanomaterials, vol. 2016, 3941501. https://doi.org/10.1155/2016/3941501
Constanda, Sabrina ; Stan, Miruna Silvia ; Ciobanu, Carmen Steluţa ; Motelica-Heino, Mikael ; Guegan, Regis ; Lafdi, Khalid ; Dinischiotu, Anca ; Predoi, Daniela. / Carbon Nanotubes-Hydroxyapatite Nanocomposites for an Improved Osteoblast Cell Response. In: Journal of Nanomaterials. 2016 ; Vol. 2016.
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