Cardiac oxidative stress and the therapeutic approaches to the intake of antioxidant supplements and physical activity

Kosar Valaei, Shima Taherkhani, Hamid Arazi*, Katsuhiko Suzuki

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Reactive oxygen species (ROS) are strongly reactive chemical entities that include oxygen regulated by enzymatic and non-enzymatic antioxidant defense mechanisms. ROS contribute significantly to cell homeostasis in the heart by regulating cell proliferation, differentiation, and excitation-contraction coupling. When ROS generation surpasses the ability of the antioxidant defense mechanisms to buffer them, oxidative stress develops, resulting in cellular and molecular disorders and eventually in heart failure. Oxidative stress is a critical factor in developing hypoxia-and ischemia-reperfusion-related cardiovascular disorders. This article aimed to discuss the role of oxidative stress in the pathophysiology of cardiac diseases such as hypertension and endothelial dysfunction. This review focuses on the various clinical events and oxidative stress associated with cardiovascular pathophysiology, highlighting the benefits of new experimental treatments such as creatine supplementation, omega-3 fatty acids, microRNAs, and antioxidant supplements in addition to physical exercise.

Original languageEnglish
Article number3483
JournalNutrients
Volume13
Issue number10
DOIs
Publication statusPublished - 2021 Oct

Keywords

  • Antioxidant supplementation
  • Cardiovascular oxidative stress
  • Exercise
  • Reactive oxygen species

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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