A highly potent cardiotonic substance, calcium isocitrate, was isolated from Aloe saponaria, using solvent partition, nonionic porous resin, and gel permeation chromatographies. Cardiac stimulant activity of synthesized stereoisomers of calcium isocitrate was demonstrated in isolated guinea pig atria.
- Aloe Saponaria—cardiac stimulation activity of various constituents, calcium isocitrate
- Stereoisomers—synthesis of calcium isocitrate stereoisomers, cardiac stimulation activity, rats, rabbits, guinea pigs
- calcium isocitrate—isolated from Aloe saponaria, cardiac stimulation of rabbit and rat, and guinea pig atria
ASJC Scopus subject areas
- Pharmaceutical Science