Cardiorespiratory fitness and the incidence of type 2 diabetes: Prospective study of Japanese men

Susumu Sawada, I. Min Lee, Takashi Muto, Kazuko Matuszaki, Steven N. Blair

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

OBJECTIVE - To investigate the association between cardiorespiratory fitness and the incidence of type 2 diabetes among Japanese men. RESEARCH DESIGN AND METHODS - This prospective cohort study was conducted in 4,747 nondiabetic Japanese men, aged 20-40 years at baseline, enrolled in 1985 with follow-up to June 1999. Cardiorespiratory fitness was measured using a cycle ergometer test, and VO2max was estimated. During a 14-year follow-up, 280 men developed type 2 diabetes. RESULTS - The age-adjusted relative risks of developing type 2 diabetes across quartiles of cardiorespiratory fitness (lowest to highest) were 1.0 (referent), 0.56 (95% CI 0.42-0.75), 0.35 (0.25-0.50), and 0.25 (0.17-0.37) (for trend, P < 0.001). After further adjustment for BMI, systolic blood pressure, family history of diabetes, smoking status, and alcohol intake, the association between type 2 diabetes risk and cardiorespiratory fitness was attenuated but remained significant (1.0, 0.78, 0.63, and 0.56, respectively; for trend, P = 0.001). CONCLUSIONS - These results indicate that a low cardiorespiratory fitness level is an important risk factor for incidence of type 2 diabetes among Japanese men.

Original languageEnglish
Pages (from-to)2918-2922
Number of pages5
JournalDiabetes Care
Volume26
Issue number10
DOIs
Publication statusPublished - 2003 Oct 1
Externally publishedYes

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Type 2 Diabetes Mellitus
Prospective Studies
Incidence
Blood Pressure
Cohort Studies
Research Design
Smoking
Alcohols
Cardiorespiratory Fitness

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Cardiorespiratory fitness and the incidence of type 2 diabetes : Prospective study of Japanese men. / Sawada, Susumu; Lee, I. Min; Muto, Takashi; Matuszaki, Kazuko; Blair, Steven N.

In: Diabetes Care, Vol. 26, No. 10, 01.10.2003, p. 2918-2922.

Research output: Contribution to journalArticle

Sawada, Susumu ; Lee, I. Min ; Muto, Takashi ; Matuszaki, Kazuko ; Blair, Steven N. / Cardiorespiratory fitness and the incidence of type 2 diabetes : Prospective study of Japanese men. In: Diabetes Care. 2003 ; Vol. 26, No. 10. pp. 2918-2922.
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