TY - JOUR
T1 - Cardiorespiratory fitness and the incidence of type 2 diabetes
T2 - Prospective study of Japanese men
AU - Sawada, Susumu S.
AU - Lee, I. Min
AU - Muto, Takashi
AU - Matuszaki, Kazuko
AU - Blair, Steven N.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/10/1
Y1 - 2003/10/1
N2 - OBJECTIVE - To investigate the association between cardiorespiratory fitness and the incidence of type 2 diabetes among Japanese men. RESEARCH DESIGN AND METHODS - This prospective cohort study was conducted in 4,747 nondiabetic Japanese men, aged 20-40 years at baseline, enrolled in 1985 with follow-up to June 1999. Cardiorespiratory fitness was measured using a cycle ergometer test, and VO2max was estimated. During a 14-year follow-up, 280 men developed type 2 diabetes. RESULTS - The age-adjusted relative risks of developing type 2 diabetes across quartiles of cardiorespiratory fitness (lowest to highest) were 1.0 (referent), 0.56 (95% CI 0.42-0.75), 0.35 (0.25-0.50), and 0.25 (0.17-0.37) (for trend, P < 0.001). After further adjustment for BMI, systolic blood pressure, family history of diabetes, smoking status, and alcohol intake, the association between type 2 diabetes risk and cardiorespiratory fitness was attenuated but remained significant (1.0, 0.78, 0.63, and 0.56, respectively; for trend, P = 0.001). CONCLUSIONS - These results indicate that a low cardiorespiratory fitness level is an important risk factor for incidence of type 2 diabetes among Japanese men.
AB - OBJECTIVE - To investigate the association between cardiorespiratory fitness and the incidence of type 2 diabetes among Japanese men. RESEARCH DESIGN AND METHODS - This prospective cohort study was conducted in 4,747 nondiabetic Japanese men, aged 20-40 years at baseline, enrolled in 1985 with follow-up to June 1999. Cardiorespiratory fitness was measured using a cycle ergometer test, and VO2max was estimated. During a 14-year follow-up, 280 men developed type 2 diabetes. RESULTS - The age-adjusted relative risks of developing type 2 diabetes across quartiles of cardiorespiratory fitness (lowest to highest) were 1.0 (referent), 0.56 (95% CI 0.42-0.75), 0.35 (0.25-0.50), and 0.25 (0.17-0.37) (for trend, P < 0.001). After further adjustment for BMI, systolic blood pressure, family history of diabetes, smoking status, and alcohol intake, the association between type 2 diabetes risk and cardiorespiratory fitness was attenuated but remained significant (1.0, 0.78, 0.63, and 0.56, respectively; for trend, P = 0.001). CONCLUSIONS - These results indicate that a low cardiorespiratory fitness level is an important risk factor for incidence of type 2 diabetes among Japanese men.
UR - http://www.scopus.com/inward/record.url?scp=0141557774&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0141557774&partnerID=8YFLogxK
U2 - 10.2337/diacare.26.10.2918
DO - 10.2337/diacare.26.10.2918
M3 - Article
C2 - 14514602
AN - SCOPUS:0141557774
VL - 26
SP - 2918
EP - 2922
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 10
ER -