Cardiorespiratory fitness, body mass index, and cancer mortality

A cohort study of Japanese men

Susumu Sawada, I. Min Lee, Hisashi Naito, Ryo Kakigi, Sataro Goto, Masaaki Kanazawa, Takashi Okamoto, Koji Tsukamoto, Takashi Muto, Hiroaki Tanaka, Steven N. Blair

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: The aim of this study is to investigate the independent and joint effects of cardiorespiratory fitnes (CRF) and body mass index (BMI) on cancer mortality in a low body mass index population Methods: We evaluated CRF and BMI in relation to cancer mortality in 8760 Japanese men. The median BMI wa 22.6 kg/m2 (IQR: 21.0-24.3). The mean follow-up period was more than 20 years. Hazard ratios and 95% CI wer obtained using a Cox proportional hazards model while adjusting for several confounding factors Results: Using the 2nd tertile of BMI (21.6-23.6 kg/m2) as reference, hazard ratios and 95% CI for the lowest tertil of BMI (18.5-21.5) were 1.26 (0.87-1.81), and 0.92 (0.64-1.34) for the highest tertile (23.7-37.4). Using the lowes tertile of CRF as reference, hazard ratios and 95% CIs for 2nd and highest tertiles of CRF were 0.78 (0.55-1.10) an 0.59 (0.40-0.88). We further calculated hazard ratios according to groups of men cross-Tabulated by tertiles of CR and BMI. Among men in the second tertile of BMI, those belonging to the lowest CRF tertile had a 53% lower ris of cancer mortality compared to those in the lowest CRF tertile (hazard ratio: 0.47, 95% CI: 0.23-0.97). Among thos in the highest BMI tertile, the corresponding hazard ratio was 0.54 (0.25-1.17) Conclusion: These results suggest that high CRF is associated with lower cancer mortality in a Japanese populatio of men with low average BMI.

Original languageEnglish
Article number1012
JournalBMC Public Health
Volume14
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1
Externally publishedYes

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Body Mass Index
Cohort Studies
Mortality
Neoplasms
Cardiorespiratory Fitness
Proportional Hazards Models
Population

Keywords

  • Epidemiology
  • Exercise
  • Maximal oxygen uptake
  • Physical activity
  • Smoking

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Cardiorespiratory fitness, body mass index, and cancer mortality : A cohort study of Japanese men. / Sawada, Susumu; Lee, I. Min; Naito, Hisashi; Kakigi, Ryo; Goto, Sataro; Kanazawa, Masaaki; Okamoto, Takashi; Tsukamoto, Koji; Muto, Takashi; Tanaka, Hiroaki; Blair, Steven N.

In: BMC Public Health, Vol. 14, No. 1, 1012, 01.01.2014.

Research output: Contribution to journalArticle

Sawada, S, Lee, IM, Naito, H, Kakigi, R, Goto, S, Kanazawa, M, Okamoto, T, Tsukamoto, K, Muto, T, Tanaka, H & Blair, SN 2014, 'Cardiorespiratory fitness, body mass index, and cancer mortality: A cohort study of Japanese men', BMC Public Health, vol. 14, no. 1, 1012. https://doi.org/10.1186/1471-2458-14-1012
Sawada, Susumu ; Lee, I. Min ; Naito, Hisashi ; Kakigi, Ryo ; Goto, Sataro ; Kanazawa, Masaaki ; Okamoto, Takashi ; Tsukamoto, Koji ; Muto, Takashi ; Tanaka, Hiroaki ; Blair, Steven N. / Cardiorespiratory fitness, body mass index, and cancer mortality : A cohort study of Japanese men. In: BMC Public Health. 2014 ; Vol. 14, No. 1.
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AU - Goto, Sataro

AU - Kanazawa, Masaaki

AU - Okamoto, Takashi

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