TY - JOUR
T1 - Cardiorespiratory Fitness Suppresses Age-Related Arterial Stiffening in Healthy Adults
T2 - A 2-Year Longitudinal Observational Study
AU - Gando, Yuko
AU - Murakami, Haruka
AU - Kawakami, Ryoko
AU - Yamamoto, Kenta
AU - Kawano, Hiroshi
AU - Tanaka, Noriko
AU - Sawada, Susumu S.
AU - Miyatake, Nobuyuki
AU - Miyachi, Motohiko
N1 - Publisher Copyright:
© 2016 Wiley Periodicals, Inc.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Cardiorespiratory fitness is negatively associated with arterial stiffness, although it is unclear whether it is associated with prospective arterial stiffness changes. The authors examined cardiorespiratory fitness and arterial stiffness progression in a 2-year follow-up study of 470 healthy men and women aged 26 to 69 years. Peak oxygen uptake (V˙O2peak) was measured at baseline using a graded cycle exercise test. Arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV) at baseline and after 2 years. Two-year changes in baPWV were significantly higher in patients in the lowest V˙O2peak tertile (28.8±7.6 cm/s) compared with those in the highest V˙O2peak tertile (-1.4±7.5 cm/s) (P=024) and were inversely correlated with V˙O2peak (r=-112, P=015). Stepwise multiple regression analysis revealed that age, glucose, baPWV, V˙O2peak, and sex were independent correlates of 2-year changes in baPWV, suggesting that higher cardiorespiratory fitness is associated with age-related arterial stiffening suppression.
AB - Cardiorespiratory fitness is negatively associated with arterial stiffness, although it is unclear whether it is associated with prospective arterial stiffness changes. The authors examined cardiorespiratory fitness and arterial stiffness progression in a 2-year follow-up study of 470 healthy men and women aged 26 to 69 years. Peak oxygen uptake (V˙O2peak) was measured at baseline using a graded cycle exercise test. Arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV) at baseline and after 2 years. Two-year changes in baPWV were significantly higher in patients in the lowest V˙O2peak tertile (28.8±7.6 cm/s) compared with those in the highest V˙O2peak tertile (-1.4±7.5 cm/s) (P=024) and were inversely correlated with V˙O2peak (r=-112, P=015). Stepwise multiple regression analysis revealed that age, glucose, baPWV, V˙O2peak, and sex were independent correlates of 2-year changes in baPWV, suggesting that higher cardiorespiratory fitness is associated with age-related arterial stiffening suppression.
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U2 - 10.1111/jch.12753
DO - 10.1111/jch.12753
M3 - Article
C2 - 26663866
AN - SCOPUS:84952333014
SN - 1524-6175
VL - 18
SP - 292
EP - 298
JO - Journal of Clinical Hypertension
JF - Journal of Clinical Hypertension
IS - 4
ER -