Catalytic α-Arylation of Ketones with Heteroaromatic Esters

Ryota Isshiki, Ryosuke Takise, Kenichiro Itami, Kei Muto, Junichiro Yamaguchi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Heteroaromatic esters were found to be applicable as an arylating agent for the Pd-catalyzed α-arylation of ketones in a decarbonylative fashion. The use of our in-house ligand, dcypt, enabled this unique bond formation. Considering the ubiquity and low cost of aromatic esters, the present work will allow for rapid access to valuable α-aryl carbonyl compounds.

Original languageEnglish
Pages (from-to)2599-2603
Number of pages5
JournalSynlett
Volume28
Issue number19
DOIs
Publication statusPublished - 2017 Dec 1

Keywords

  • aromatic esters
  • decarbonylative coupling
  • heteroarenes
  • ketones
  • palladium
  • α-arylation

ASJC Scopus subject areas

  • Organic Chemistry

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