Catalytic α-Arylation of Ketones with Heteroaromatic Esters

Ryota Isshiki, Ryosuke Takise, Kenichiro Itami, Kei Muto, Junichiro Yamaguchi

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    Heteroaromatic esters were found to be applicable as an arylating agent for the Pd-catalyzed α-arylation of ketones in a decarbonylative fashion. The use of our in-house ligand, dcypt, enabled this unique bond formation. Considering the ubiquity and low cost of ­aromatic esters, the present work will allow for rapid access to valuable α-aryl carbonyl compounds.

    Original languageEnglish
    JournalSynlett
    DOIs
    Publication statusAccepted/In press - 2017 Sep 26

    Keywords

    • aromatic esters
    • decarbonylative coupling
    • heteroarenes
    • ketones
    • palladium
    • α-arylation

    ASJC Scopus subject areas

    • Organic Chemistry

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