Catalytic α-Arylation of Ketones with Heteroaromatic Esters

Ryota Isshiki, Ryosuke Takise, Kenichiro Itami, Kei Muto, Junichiro Yamaguchi

    Research output: Contribution to journalArticle

    12 Citations (Scopus)

    Abstract

    Heteroaromatic esters were found to be applicable as an arylating agent for the Pd-catalyzed α-arylation of ketones in a decarbonylative fashion. The use of our in-house ligand, dcypt, enabled this unique bond formation. Considering the ubiquity and low cost of ­aromatic esters, the present work will allow for rapid access to valuable α-aryl carbonyl compounds.

    Original languageEnglish
    JournalSynlett
    DOIs
    Publication statusAccepted/In press - 2017 Sep 26

    Fingerprint

    Ketones
    Esters
    Carbonyl compounds
    Ligands
    Costs

    Keywords

    • aromatic esters
    • decarbonylative coupling
    • heteroarenes
    • ketones
    • palladium
    • α-arylation

    ASJC Scopus subject areas

    • Organic Chemistry

    Cite this

    Catalytic α-Arylation of Ketones with Heteroaromatic Esters. / Isshiki, Ryota; Takise, Ryosuke; Itami, Kenichiro; Muto, Kei; Yamaguchi, Junichiro.

    In: Synlett, 26.09.2017.

    Research output: Contribution to journalArticle

    Isshiki, Ryota ; Takise, Ryosuke ; Itami, Kenichiro ; Muto, Kei ; Yamaguchi, Junichiro. / Catalytic α-Arylation of Ketones with Heteroaromatic Esters. In: Synlett. 2017.
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