Catalytic three-component C-C bond forming dearomatization of bromoarenes with malonates and diazo compounds

Hiroki Kato, Itsuki Musha, Masaaki Komatsuda, Kei Muto, Junichiro Yamaguchi

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

A Pd-catalyzed dearomative three-component C-C bond formation of bromoarenes with diazo compounds and malonates was developed. Various bromoarenes ranging from benzenoids to azines and heteroles were transformed to the corresponding substituted alicyclic molecules. The key to this reaction is the generation of a benzyl-palladium intermediate, which reacts with malonates to form a Pd-O-enolate species. Strikingly, the present method enabled rapid access to multi-substituted alicycles through subsequent elaboration of dearomatized products. This journal is

Original languageEnglish
Pages (from-to)8779-8784
Number of pages6
JournalChemical Science
Volume11
Issue number33
DOIs
Publication statusPublished - 2020 Sep 7

ASJC Scopus subject areas

  • Chemistry(all)

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